The effect of gastrointestinal hormones on the pertechnetate imaging of ectopic gastric mucosa in experimental Meckel's diverticulum

George N Sfakianakis, G. F. Anderson, D. R. King, E. T. Boles

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Meckel's diverticula were simulated in 12 dogs by implanting vascularized patches of gastric wall onto Roux-en-Y loops of distal ileum. All animals had camera imaging studies every 10 min for 60 min, with computer acquisition (1-min frames) following intravenous injection of 2 mCi of pertechnetate. The scintigrams were repeated following (a) subcutaneous injection of pentagastrin (6 μg/kg) 15 min before injection of pertechnetate; (b) intravenous injection of glucagon (50 μg/kg) 10 min after the tracer injection; (c) pretreatment with pentagastrin plus glucagon as above; and (d) pretreatment with pentagastrin plus secretin (1 unit Boots/kg intravenously after the pertechnetate). Patches of ectopic gastric mucosa as small as 1 cm2 were visualized. Pentagastrin alone accelerated accumulation of the tracer but resulted in a decrease in the target-to-background ratio. Glucagon alone enhanced late gastric mucosal activity by preventing washout of the intraluminal activity. The combination of pentagastrin and glucagon enhanced visualization and kept background activity lowest. These findings indicate a potential role for glucagon in the diagnosis of ectopic gastric mucosa in humans.

Original languageEnglish
Pages (from-to)678-683
Number of pages6
JournalJournal of Nuclear Medicine
Volume22
Issue number8
StatePublished - Jan 1 1981
Externally publishedYes

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Gastrointestinal Hormones
Meckel Diverticulum
Sodium Pertechnetate Tc 99m
Pentagastrin
Gastric Mucosa
Glucagon
Intravenous Injections
Stomach
Roux-en-Y Anastomosis
Injections
Secretin
Subcutaneous Injections
Ileum
Dogs

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

The effect of gastrointestinal hormones on the pertechnetate imaging of ectopic gastric mucosa in experimental Meckel's diverticulum. / Sfakianakis, George N; Anderson, G. F.; King, D. R.; Boles, E. T.

In: Journal of Nuclear Medicine, Vol. 22, No. 8, 01.01.1981, p. 678-683.

Research output: Contribution to journalArticle

Sfakianakis, George N ; Anderson, G. F. ; King, D. R. ; Boles, E. T. / The effect of gastrointestinal hormones on the pertechnetate imaging of ectopic gastric mucosa in experimental Meckel's diverticulum. In: Journal of Nuclear Medicine. 1981 ; Vol. 22, No. 8. pp. 678-683.
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