Abstract
There is a crisis of early childhood maltreatment in the United States. In 2012, the United States Department of Health and Human Services noted 3.4 million referrals to childhood protective services, of which the majority related to child abuse or neglect. Early life stress (ELS) due to childhood abuse and/or neglect can generate life-long consequences. ELS has been associated with disrupted neurodevelopment that can yield social, emotional, and cognitive impairment; adult medical and psychiatric disorders; disability; and even earlier death. Some studies have shown that adults with major depression and ELS respond less well to conventional treatments than adults who did not experience early life stress. In this article, we review some of the neurobiological and epigenetic studies that explore this association.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-37 |
| Number of pages | 3 |
| Journal | Innovations in Clinical Neuroscience |
| Volume | 16 |
| Issue number | 1-2 |
| State | Published - Jan 1 2019 |
| Externally published | Yes |
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Keywords
- Adult psychiatric disorder
- Childhood abuse
- Early life stress
- Major depressive disorder
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
Cite this
The effect of early life stress on adult psychiatric disorders. / Targum, Steven D.; Nemeroff, Charles.
In: Innovations in Clinical Neuroscience, Vol. 16, No. 1-2, 01.01.2019, p. 35-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of early life stress on adult psychiatric disorders
AU - Targum, Steven D.
AU - Nemeroff, Charles
PY - 2019/1/1
Y1 - 2019/1/1
N2 - There is a crisis of early childhood maltreatment in the United States. In 2012, the United States Department of Health and Human Services noted 3.4 million referrals to childhood protective services, of which the majority related to child abuse or neglect. Early life stress (ELS) due to childhood abuse and/or neglect can generate life-long consequences. ELS has been associated with disrupted neurodevelopment that can yield social, emotional, and cognitive impairment; adult medical and psychiatric disorders; disability; and even earlier death. Some studies have shown that adults with major depression and ELS respond less well to conventional treatments than adults who did not experience early life stress. In this article, we review some of the neurobiological and epigenetic studies that explore this association.
AB - There is a crisis of early childhood maltreatment in the United States. In 2012, the United States Department of Health and Human Services noted 3.4 million referrals to childhood protective services, of which the majority related to child abuse or neglect. Early life stress (ELS) due to childhood abuse and/or neglect can generate life-long consequences. ELS has been associated with disrupted neurodevelopment that can yield social, emotional, and cognitive impairment; adult medical and psychiatric disorders; disability; and even earlier death. Some studies have shown that adults with major depression and ELS respond less well to conventional treatments than adults who did not experience early life stress. In this article, we review some of the neurobiological and epigenetic studies that explore this association.
KW - Adult psychiatric disorder
KW - Childhood abuse
KW - Early life stress
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85067953334&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067953334&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85067953334
VL - 16
SP - 35
EP - 37
JO - Psychiatry
JF - Psychiatry
SN - 2158-8333
IS - 1-2
ER -