The effect of dexamethasone on urinary acidification.

G. Perez, C. Abraira, J. R. Oster, L. Lespier, C. A. Vaamonde

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume150
Issue number3
StatePublished - Dec 1 1975

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Acidification
Dexamethasone
Urine
Acids
dexamethasone 21-phosphate
Ammonium Compounds
Phosphorus Acids
Respiratory Alkalosis
Mineralocorticoids
Glucocorticoids
Oral Administration
Creatinine
Healthy Volunteers
Potassium
Phosphorus
Kidney
Blood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Perez, G., Abraira, C., Oster, J. R., Lespier, L., & Vaamonde, C. A. (1975). The effect of dexamethasone on urinary acidification. Proceedings of the Society for Experimental Biology and Medicine, 150(3), 606-611.

The effect of dexamethasone on urinary acidification. / Perez, G.; Abraira, C.; Oster, J. R.; Lespier, L.; Vaamonde, C. A.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 150, No. 3, 01.12.1975, p. 606-611.

Research output: Contribution to journalArticle

Perez, G, Abraira, C, Oster, JR, Lespier, L & Vaamonde, CA 1975, 'The effect of dexamethasone on urinary acidification.', Proceedings of the Society for Experimental Biology and Medicine, vol. 150, no. 3, pp. 606-611.
Perez G, Abraira C, Oster JR, Lespier L, Vaamonde CA. The effect of dexamethasone on urinary acidification. Proceedings of the Society for Experimental Biology and Medicine. 1975 Dec 1;150(3):606-611.
Perez, G. ; Abraira, C. ; Oster, J. R. ; Lespier, L. ; Vaamonde, C. A. / The effect of dexamethasone on urinary acidification. In: Proceedings of the Society for Experimental Biology and Medicine. 1975 ; Vol. 150, No. 3. pp. 606-611.
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