Abstract
Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.
| Original language | English |
|---|---|
| Pages (from-to) | 606-611 |
| Number of pages | 6 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 150 |
| Issue number | 3 |
| State | Published - Dec 1 1975 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The effect of dexamethasone on urinary acidification. / Perez, G.; Abraira, C.; Oster, J. R.; Lespier, L.; Vaamonde, C. A.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 150, No. 3, 01.12.1975, p. 606-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of dexamethasone on urinary acidification.
AU - Perez, G.
AU - Abraira, C.
AU - Oster, J. R.
AU - Lespier, L.
AU - Vaamonde, C. A.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.
AB - Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016637978&partnerID=8YFLogxK
M3 - Article
C2 - 1793
AN - SCOPUS:0016637978
VL - 150
SP - 606
EP - 611
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 3
ER -