Abstract
The systemic component of combined modality therapeutic programs has influenced both the selection of the approach to local control and survival in a number of tumor types. The more effective systemic therapy is against metastatic cancer by itself, the greater the impact on local control and survival. This observation is consistent with the invariable inverse relationship between curability and tumor cell number. For some common cancers, local control is good, but survival remains poor because of the inability to deal effectively with micrometastases. Improved systemic treatment is likely to have an impact on survival may shift local control measures, in some cases, to radiation therapy or lesser surgery without radiation therapy. There remains a substantial number of tumor types where both local control and survival is poor. In these tumors, improvement in local control by itself is not likely to improve survival because of the presence of micrometastases, but such improvements must occur before we can have a true evaluation of the systemic treatment of micrometastases in these tumors. The recent understanding that the metastatic process is under genetic control and the cloning of metastases genes offers a substantial opportunity to control this process and influence both local control and survival.
| Original language | English |
|---|---|
| Pages (from-to) | 487-501 |
| Number of pages | 15 |
| Journal | International journal of radiation oncology, biology, physics |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1986 |
| Externally published | Yes |
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Keywords
- Anal cancer
- Breast cancer
- Combined modality
- Lung cancer
- Lymphoma
- Sarcomas
- Wilms' tumor, Systemic therapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
The effect of combined modality therapy on local control and survival. / DeVita, V. T.; Lippman, Marc E; Hubbard, S. M.; Ihde, D. C.; Rosenberg, S. A.
In: International journal of radiation oncology, biology, physics, Vol. 12, No. 4, 01.01.1986, p. 487-501.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of combined modality therapy on local control and survival
AU - DeVita, V. T.
AU - Lippman, Marc E
AU - Hubbard, S. M.
AU - Ihde, D. C.
AU - Rosenberg, S. A.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The systemic component of combined modality therapeutic programs has influenced both the selection of the approach to local control and survival in a number of tumor types. The more effective systemic therapy is against metastatic cancer by itself, the greater the impact on local control and survival. This observation is consistent with the invariable inverse relationship between curability and tumor cell number. For some common cancers, local control is good, but survival remains poor because of the inability to deal effectively with micrometastases. Improved systemic treatment is likely to have an impact on survival may shift local control measures, in some cases, to radiation therapy or lesser surgery without radiation therapy. There remains a substantial number of tumor types where both local control and survival is poor. In these tumors, improvement in local control by itself is not likely to improve survival because of the presence of micrometastases, but such improvements must occur before we can have a true evaluation of the systemic treatment of micrometastases in these tumors. The recent understanding that the metastatic process is under genetic control and the cloning of metastases genes offers a substantial opportunity to control this process and influence both local control and survival.
AB - The systemic component of combined modality therapeutic programs has influenced both the selection of the approach to local control and survival in a number of tumor types. The more effective systemic therapy is against metastatic cancer by itself, the greater the impact on local control and survival. This observation is consistent with the invariable inverse relationship between curability and tumor cell number. For some common cancers, local control is good, but survival remains poor because of the inability to deal effectively with micrometastases. Improved systemic treatment is likely to have an impact on survival may shift local control measures, in some cases, to radiation therapy or lesser surgery without radiation therapy. There remains a substantial number of tumor types where both local control and survival is poor. In these tumors, improvement in local control by itself is not likely to improve survival because of the presence of micrometastases, but such improvements must occur before we can have a true evaluation of the systemic treatment of micrometastases in these tumors. The recent understanding that the metastatic process is under genetic control and the cloning of metastases genes offers a substantial opportunity to control this process and influence both local control and survival.
KW - Anal cancer
KW - Breast cancer
KW - Combined modality
KW - Lung cancer
KW - Lymphoma
KW - Sarcomas
KW - Wilms' tumor, Systemic therapy
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UR - http://www.scopus.com/inward/citedby.url?scp=0022500819&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(86)90056-8
DO - 10.1016/0360-3016(86)90056-8
M3 - Article
C2 - 3009367
AN - SCOPUS:0022500819
VL - 12
SP - 487
EP - 501
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 4
ER -