The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak; P. Hahn; V. Pardo; E. Monkus; D. Alzamora

doi:10.1016/0020-711X(74)90154-2

The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak, P. Hahn, V. Pardo, E. Monkus, D. Alzamora

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

Original language	English
Journal	International Journal of Biochemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0020-711X(74)90154-2
State	Published - Jan 1 1974

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Keywords

adipose tissue
carnitine
mitochondria
Newborn

ASJC Scopus subject areas

Biochemistry

Cite this

Novak, M., Hahn, P., Pardo, V., Monkus, E., & Alzamora, D. (1974). The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue. International Journal of Biochemistry, 5(2). https://doi.org/10.1016/0020-711X(74)90154-2

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10.1016/0020-711X(74)90154-2