The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak, P. Hahn, V. Pardo, E. Monkus, D. Alzamora

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)223-224,IN1-IN2,225-230,IN3-IN4,231-234
JournalInternational Journal of Biochemistry
Volume5
Issue number2
DOIs
StatePublished - Feb 1974

Keywords

  • adipose tissue
  • carnitine
  • mitochondria
  • Newborn

ASJC Scopus subject areas

  • Biochemistry

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