The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak, P. Hahn, V. Pardo, E. Monkus, D. Alzamora

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Abstract

1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

Original languageEnglish
JournalInternational Journal of Biochemistry
Volume5
Issue number2
DOIs
StatePublished - Jan 1 1974

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Keywords

  • adipose tissue
  • carnitine
  • mitochondria
  • Newborn

ASJC Scopus subject areas

  • Biochemistry

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