The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak; P. Hahn; V. Pardo; E. Monkus; D. Alzamora

doi:10.1016/0020-711X(74)90154-2

The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

M. Novak, P. Hahn, V. Pardo, E. Monkus, D. Alzamora

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

Original language	English (US)
Pages (from-to)	223-224,IN1-IN2,225-230,IN3-IN4,231-234
Journal	International Journal of Biochemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0020-711X(74)90154-2
State	Published - Feb 1974
Externally published	Yes

Keywords

adipose tissue
carnitine
mitochondria
Newborn

ASJC Scopus subject areas

Biochemistry

Access to Document

10.1016/0020-711X(74)90154-2

Cite this

@article{0efb17e138e848edb2ebf3474bf24ebb,

title = "The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue",

abstract = "1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.",

keywords = "adipose tissue, carnitine, mitochondria, Newborn",

author = "M. Novak and P. Hahn and V. Pardo and E. Monkus and D. Alzamora",

note = "Funding Information: Supported by NIH (NICZID) Grant I ROI HD 04984%01A2, Easter Seal Research Foundation Grant R-7127, and a grant from M.R.C. (Canada). The L-carnitine was the generous gift of Otsuka Pharmaceutical Factory, Osaka, Japan.",

year = "1974",

month = feb,

doi = "10.1016/0020-711X(74)90154-2",

language = "English (US)",

volume = "5",

pages = "223--224,IN1--IN2,225--230,IN3--IN4,231--234",

journal = "International Journal of Biochemistry",

issn = "1357-2725",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

AU - Novak, M.

AU - Hahn, P.

AU - Pardo, V.

AU - Monkus, E.

AU - Alzamora, D.

N1 - Funding Information: Supported by NIH (NICZID) Grant I ROI HD 04984%01A2, Easter Seal Research Foundation Grant R-7127, and a grant from M.R.C. (Canada). The L-carnitine was the generous gift of Otsuka Pharmaceutical Factory, Osaka, Japan.

PY - 1974/2

Y1 - 1974/2

N2 - 1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

AB - 1. 1. Carnitine added to mitochondria isolated from human newborn white adipose tissue by a new method enhances oxygen consumption, while deoxycarnitine inhibits it. 2. 2. These effects are not seen in adult tissue. 3. 3. Isolated adipose tissue cells from the newborn can be separated into large and small cells. Mitochondria isolated from the former are insensitive to carnitine, while mitochondria isolated from the small cells show increased oxygen consumption on addition of carnitine. 4. 5. It is suggested that these small cells may produce heat by fatty acid oxidation.

KW - adipose tissue

KW - carnitine

KW - mitochondria

KW - Newborn

UR - http://www.scopus.com/inward/record.url?scp=49549152097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49549152097&partnerID=8YFLogxK

U2 - 10.1016/0020-711X(74)90154-2

DO - 10.1016/0020-711X(74)90154-2

M3 - Article

AN - SCOPUS:49549152097

VL - 5

SP - 223-224,IN1-IN2,225-230,IN3-IN4,231-234

JO - International Journal of Biochemistry

JF - International Journal of Biochemistry

SN - 1357-2725

IS - 2

ER -

The effect of carnitine on respiration of mitochondria obtained from newborn and adult human subcutaneous white adipose tissue

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this