The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation

Marc Gualtieri, Yanping Zhang, Keith Candiotti, Sujata Yavagal, Carlos A. Medina, Peter Takacs

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Aims: To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. Results: Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03,P < 0.01). Conclusion: The decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh.

Original languageEnglish (US)
Pages (from-to)435-437
Number of pages3
JournalNeurourology and Urodynamics
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • Mesh
  • Proliferation
  • Smooth muscle cells
  • Xenograft

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

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