The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes

André Mercanzini, Sai Reddy, Marc Boers, Diana Velluto, Arnaud Bertsch, Jeffrey Hubbell, Philippe Renaud

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

This study describes how drug eluting coatings affect the signal quality of implantable microelectrodes. Polyimide-Platinum neural probes were microfabricated and coated with a biodegradable polymer loaded with drug eluting nanoparticles. Electrical impedance spectroscopy was used to study how the coating affects electrical recording and stimulation characteristics. The measurements were performed in vitro and it was found that the biodegradable film slightly modified the measured impedance phase by +3° at 10kHz but not the magnitude. This change in impedance is permanent but does not adversely affect the recording and stimulation characteristics of the device. This result demonstrates the compatibility of controlled release drug coatings with neural probes.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages1377-1380
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France
Duration: Jun 10 2007Jun 14 2007

Publication series

NameTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
CountryFrance
CityLyon
Period6/10/076/14/07

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Keywords

  • Drug delivery
  • Electrical impedance spectroscopy
  • Neural probes

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Mercanzini, A., Reddy, S., Boers, M., Velluto, D., Bertsch, A., Hubbell, J., & Renaud, P. (2007). The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1377-1380). [4300399] (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300399