The effect of beta irradiation on monkey tenon's capsule fibroblasts in tissue culture

Juan A. Nevárez, Richard K Parrish, Dale K. Heuer, Anthony S. Hajek, Pavel V. Houdek, Kim S. Mallick

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fibroblast proliferation with subsequent bleb scarring is a major cause of filtering surgery failure. To investigate possible antiproliferative effects of beta radiation, owl monkey Tenon's capsule fibroblasts in tissue culture were irradiated to doses of 30, 100, 300, 1,000, and 3,000 rads with a linear accelerator and to doses of 95,285, and 950 rads with a Strontium-90 applicator. The irradiated cell proliferation expressed as the percentage of the non-irradiated control growth on the third and seventh days, respectively, after beta irradiation was: 97% and 96% after 30 rads; 72% and 90% after 100 rads; 48% and 44% after 300 rads; 39% and 14% after 1,000 rads; and 39% and 14% after 3,000 rads. Similar effects on cell proliferation were observed with the Strontium-90 applicator. The inhibitory effect of beta irradiation on fibroblast proliferation in tissue culture suggests that beta irradiation after filtering surgery may reduce postoperative bleb scarring.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalCurrent Eye Research
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1987

Fingerprint

Tenon Capsule
Filtering Surgery
Haplorhini
Strontium
Fibroblasts
Blister
Cicatrix
Aotidae
Cell Proliferation
Beta Particles
Particle Accelerators
Growth

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The effect of beta irradiation on monkey tenon's capsule fibroblasts in tissue culture. / Nevárez, Juan A.; Parrish, Richard K; Heuer, Dale K.; Hajek, Anthony S.; Houdek, Pavel V.; Mallick, Kim S.

In: Current Eye Research, Vol. 6, No. 5, 01.01.1987, p. 719-723.

Research output: Contribution to journalArticle

Nevárez, Juan A. ; Parrish, Richard K ; Heuer, Dale K. ; Hajek, Anthony S. ; Houdek, Pavel V. ; Mallick, Kim S. / The effect of beta irradiation on monkey tenon's capsule fibroblasts in tissue culture. In: Current Eye Research. 1987 ; Vol. 6, No. 5. pp. 719-723.
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