TY - JOUR
T1 - The effect of beta irradiation on monkey tenon's capsule fibroblasts in tissue culture
AU - Nevárez, Juan A.
AU - Parrish, Richard K.
AU - Heuer, Dale K.
AU - Hajek, Anthony S.
AU - Houdek, Pavel V.
AU - Mallick, Kim S.
N1 - Funding Information:
ACKNOWLEDGEMENTS This study was supported in part by Public Health Service Core Grant P30-EY-02180, Department of Health and Human Services, National Institutes of Health, National Eye Institute, Bethesda, MD; National Glaucoma Research, a program of the American Health Assistance Foundation, Beltsville, MD: the Helena Rubinstein Foundation, New York, NY; the George K. Zain Foundation Fund; and Research to Prevent Blindness, lnc., New Yo&, NY.
PY - 1987
Y1 - 1987
N2 - Fibroblast proliferation with subsequent bleb scarring is a major cause of filtering surgery failure. To investigate possible antiproliferative effects of beta radiation, owl monkey Tenon's capsule fibroblasts in tissue culture were irradiated to doses of 30, 100, 300, 1,000, and 3,000 rads with a linear accelerator and to doses of 95,285, and 950 rads with a Strontium-90 applicator. The irradiated cell proliferation expressed as the percentage of the non-irradiated control growth on the third and seventh days, respectively, after beta irradiation was: 97% and 96% after 30 rads; 72% and 90% after 100 rads; 48% and 44% after 300 rads; 39% and 14% after 1,000 rads; and 39% and 14% after 3,000 rads. Similar effects on cell proliferation were observed with the Strontium-90 applicator. The inhibitory effect of beta irradiation on fibroblast proliferation in tissue culture suggests that beta irradiation after filtering surgery may reduce postoperative bleb scarring.
AB - Fibroblast proliferation with subsequent bleb scarring is a major cause of filtering surgery failure. To investigate possible antiproliferative effects of beta radiation, owl monkey Tenon's capsule fibroblasts in tissue culture were irradiated to doses of 30, 100, 300, 1,000, and 3,000 rads with a linear accelerator and to doses of 95,285, and 950 rads with a Strontium-90 applicator. The irradiated cell proliferation expressed as the percentage of the non-irradiated control growth on the third and seventh days, respectively, after beta irradiation was: 97% and 96% after 30 rads; 72% and 90% after 100 rads; 48% and 44% after 300 rads; 39% and 14% after 1,000 rads; and 39% and 14% after 3,000 rads. Similar effects on cell proliferation were observed with the Strontium-90 applicator. The inhibitory effect of beta irradiation on fibroblast proliferation in tissue culture suggests that beta irradiation after filtering surgery may reduce postoperative bleb scarring.
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U2 - 10.3109/02713688709034835
DO - 10.3109/02713688709034835
M3 - Article
C2 - 3595181
AN - SCOPUS:0023185828
VL - 6
SP - 719
EP - 723
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - 5
ER -