The effect of antenatal surgery on craniofacial growth in a sheep model

Seth R. Thaller, Joseph Mele, James Hoyt

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The purpose of this investigation was to evaluate the effect of antenatal palatal surgery in a sheep model. At 75 to 90 days of gestation, 20 fetuses underwent surgical in utero manipulation of their palates with the incision and elevation of bilateral bipedicled mucoperiosteal flaps. Sixteen of the 20 sheep (80 percent) went on to a normal full-term delivery. The palates and facial appearances were grossly evaluated, and detailed measurements were made of the palates. The data underwent statistical analysis. We were unable to discern any differences between the experimental group and the age- matched controls. Antenatal palatal surgery appeared to have no effect on craniofacial growth and development.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalPlastic and reconstructive surgery
Issue number1
StatePublished - Jul 1995
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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