The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep

K. Tomioka, R. Garrido, J. S. Stevenson, W. M. Abraham

Research output: Contribution to journalArticle

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Abstract

In this study we examined the effects of an orally active leukotriene (LT) antagonist YM-16638 [[5-[[3-(4-acetyl-3-hydroxy- 2-propyl-phenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio] acetic acid on antigen-induced early and late responses in allergic sheep. For all studies YM-16638 was administered via intragastric tube 1 h before airway challenge with Ascaris suum antigen. Six allergic sheep were challenged on four occassions (2 control and 2 drug trials) earch ≥14 days apart and the tests were conducted in the following order: control-1; YM-16638 30 mg/kg; control-2; YM-16638 10 mg/kg. Specific lung resistance (SRL) was used as an index of the airway response to antigen and was measured before and serially after antigen challenge. In both control trials antigen challenge resulted in significant early and late airway responses (i.e. increases in SRL); however, there was a significant difference between the peak late increases of SRL in control-1 (206%) and control-2 (115%) suggesting a carry-over effect of the 30 mg/kg dose of YM-16638. At both doses, YM-16638 reduced the early response and blocked the late response when compared to either control trial. These results suggest that sulfidopeptide LTs contribute to both antigen-induced early and late airway responses in allergic sheep.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume36
Issue number1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Leukotriene Antagonists
Sheep
Antigens
Ascaris suum
Drug and Narcotic Control
Acetic Acid
YM 16638
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. / Tomioka, K.; Garrido, R.; Stevenson, J. S.; Abraham, W. M.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 36, No. 1, 01.01.1989, p. 43-47.

Research output: Contribution to journalArticle

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