The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease

Dylan G. Harwood, Ari Kalechstein, Warren W. Barker, Silvia Strauman, Peter St George-Hyslop, Casandra Iglesias, David Loewenstein, Ranjan Duara

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE ε4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. Design: Cross-sectional study of AD patients evaluated at a University-affiliated outpatient memory disorders clinic. Subjects: A clinic-based cohort of white non-Hispanic (WNH; n=397), white Hispanic (WH; n=264), and African-American (AA; n=24) patients diagnosed with possible or probable AD according to NINCDS-ADRDA diagnostic criteria. Measurements: The age of onset of AD was obtained from a knowledgeable family member. All patients were assessed for APOE genotype. History of alcohol and tobacco consumption prior to the onset of dementia was obtained via an interview with the patient and the primary caregiver. A history of heavy drinking was defined as >2 drinks per day and a history of heavy smoking was defined as ≥1 pack per day. Results: Presence of an APOE ε4 allele, a history of heavy drinking, or a history of heavy smoking were each associated with an earlier onset of AD by 2-3 years. Patients with all three risk factors were likely to be diagnosed with AD nearly 10 years earlier than those with none of the risk factors. Conclusion: The results suggest that APOE ε4 and heavy drinking and heavy smoking lower the age of onset for AD in an additive fashion.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalInternational Journal of Geriatric Psychiatry
Volume25
Issue number5
DOIs
StatePublished - May 1 2010

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Tobacco Use
Apolipoproteins E
Age of Onset
Alcohol Drinking
Alzheimer Disease
Genotype
Apolipoprotein E4
Smoking
Alleles
Drinking
Independent Living
Memory Disorders
Hispanic Americans
Ethnic Groups
African Americans
Caregivers
Dementia
Outpatients
Cross-Sectional Studies
Alcohols

Keywords

  • Age of onset
  • Alzheimer's disease
  • APOE
  • Drinking
  • Smoking

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Harwood, D. G., Kalechstein, A., Barker, W. W., Strauman, S., George-Hyslop, P. S., Iglesias, C., ... Duara, R. (2010). The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease. International Journal of Geriatric Psychiatry, 25(5), 511-518. https://doi.org/10.1002/gps.2372

The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease. / Harwood, Dylan G.; Kalechstein, Ari; Barker, Warren W.; Strauman, Silvia; George-Hyslop, Peter St; Iglesias, Casandra; Loewenstein, David; Duara, Ranjan.

In: International Journal of Geriatric Psychiatry, Vol. 25, No. 5, 01.05.2010, p. 511-518.

Research output: Contribution to journalArticle

Harwood, Dylan G. ; Kalechstein, Ari ; Barker, Warren W. ; Strauman, Silvia ; George-Hyslop, Peter St ; Iglesias, Casandra ; Loewenstein, David ; Duara, Ranjan. / The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease. In: International Journal of Geriatric Psychiatry. 2010 ; Vol. 25, No. 5. pp. 511-518.
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