The Effect of a Community-Based Exercise Program on Inflammation, Metabolic Risk, and Fitness Levels Among Persons Living with HIV/AIDS

Stacy E. Cutrono, John E Lewis, Arlette Perry, Joseph Signorile, Eduard Tiozzo, Kevin Jacobs

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The human immunodeficiency virus (HIV) pandemic remains a top national health priority. Chronic inflammation may be a critical component in the disease course of HIV as C-reactive protein (CRP) is elevated and associated with increased mortality. This study examined the effect of 3 months of combined aerobic and resistance exercise training among a diverse cohort of HIV-infected men and women. The fixed effect of time for CRP was found to be non-significant (F[1,57.3] = 1.7, p = 0.19). There was a significant fixed effect for time for upper body (F[1,51.6] = 18.1, p <0.05) and lower body strength (F[1,48.0] = 15.7, p <0.05) and significant declines in diastolic blood pressure (p = 0.002) and waist circumference (p = 0.027). Though levels of CRP were not impacted after 3 months training, participants demonstrated a significant increase in muscular strength as well as beneficial changes in metabolic risk factors. Future studies should focus on determining the optimal exercise intervention length and mode to reduce inflammation among individuals living with HIV.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Nov 25 2015

Fingerprint

Acquired Immunodeficiency Syndrome
HIV
C-Reactive Protein
Exercise
Inflammation
Blood Pressure
Health Priorities
Resistance Training
Waist Circumference
Pandemics
Mortality

Keywords

  • Aerobic exercise
  • C-reactive protein
  • Human immunodeficiency virus
  • Inflammation
  • Metabolic risk
  • Resistance training

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

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abstract = "The human immunodeficiency virus (HIV) pandemic remains a top national health priority. Chronic inflammation may be a critical component in the disease course of HIV as C-reactive protein (CRP) is elevated and associated with increased mortality. This study examined the effect of 3 months of combined aerobic and resistance exercise training among a diverse cohort of HIV-infected men and women. The fixed effect of time for CRP was found to be non-significant (F[1,57.3] = 1.7, p = 0.19). There was a significant fixed effect for time for upper body (F[1,51.6] = 18.1, p <0.05) and lower body strength (F[1,48.0] = 15.7, p <0.05) and significant declines in diastolic blood pressure (p = 0.002) and waist circumference (p = 0.027). Though levels of CRP were not impacted after 3 months training, participants demonstrated a significant increase in muscular strength as well as beneficial changes in metabolic risk factors. Future studies should focus on determining the optimal exercise intervention length and mode to reduce inflammation among individuals living with HIV.",
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