The effect of a brain lesion on bone healing

R. F. Spencer, R. Bullock, K. Cooper, R. J. Norman, P. J. Becker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Using a feline model, the effects of stereotaxic brain lesions producing unilateral spasticity on bilateral fibular osteotomies were observed. Healing in spastic limbs occurred with more new bone formation than on the contralateral (control) side. Union appeared to be slightly faster in spastic limbs. Histomorphometric analysis of resected fibular specimens following union revealed little difference between spastic and non-spastic limbs. When these brain-lesioned animals were compared with a group with identical osteotomies but no brain lesions in respect of various systemic biochemical and endocrine parameters, no differences were found.

Original languageEnglish (US)
Pages (from-to)646-650
Number of pages5
JournalJournal of Orthopaedic Research
Issue number5
StatePublished - Sep 1990
Externally publishedYes


  • Brain lesion
  • Fracture healing
  • Spasticity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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