The effect of γ-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells

Elika Samandari, Theresa Visarius, Jean Marc Zingg, Angelo Azzi

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The effect of vitamin E on proliferation, integrin expression, adhesion, and migration in human glioma cells has been studied. γ-tocopherol at 50 μM concentration exerted more inhibitory effect than α-tocopherol at the same concentration on glioma cell proliferation. Integrin α5 and β1 protein levels were increased upon both α- and γ-tocopherol treatments. In parallel, an increase in the α5β1 heterodimer cell surface expression was observed. The tocopherols inhibited glioma cell-binding to fibronectin where γ-tocopherol treatment induced glioma cell migration. Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin α5 and β1 expression. Cell adhesion is also negatively affected by tocopherols, despite a small increase in the surface appearance of the α5β1 heterodimer. Cell migration is stimulated by γ-tocopherol. It is concluded that α5 and β1 integrin expression and surface appearance are not sufficient to explain all the observations and that other integrins or in general other factors may be associated with these events.

Original languageEnglish (US)
Pages (from-to)1329-1333
Number of pages5
JournalBiochemical and biophysical research communications
Volume342
Issue number4
DOIs
StatePublished - Apr 21 2006
Externally publishedYes

Keywords

  • Cell adhesion
  • Cell migration
  • Cell proliferation
  • Glioma cells
  • Integrins
  • Tocopherol
  • Vitamin E

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The effect of γ-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells'. Together they form a unique fingerprint.

Cite this