The effect of β-(Tyr9)melanotropin-(9-18) on active avoidance behavior, electroconvulsive shock-induced amnesia and T-discrimination learning of rats

Gyula Telegdy, László Vécsei, Ibolya Bollók, Andrew V. Schally

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effect of β-(Tyr9)melanotropin-(9-18) was investigated on active avoidance behavior, electroconvulsive shock (ECS)-induced amnesia and T-discrimination learning in rats. The decapeptide inhibited the extinction of active avoidance behavior. It was also able to block ECS-induced amnesia if the treatment was performed immediately, or 4 hr or 20 hr after the ECS. In the T-discrimination paradigm the peptide facilitated spatial discrimination learning and reversal learning. These results suggest that β-(Tyr9)melanotropin-(9-18) can influence learning and memory processes in different behavioral tests.

Original languageEnglish (US)
Pages (from-to)11-13
Number of pages3
JournalPeptides
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Keywords

  • Amnesia
  • Avoidance behavior
  • T-discrimination learning
  • β-(Tyr)MSH

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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