The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone

Itaru Kimura, D. R. Ayyar

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3 Scopus citations


Kimura, I. and Ayyar, D.R. The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405408-A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathing difficulty due to weakness in the respiratory muscles showed improvements after long-term administration of prednisolone. Electrophysiological studies before treatment revealed decreased amplitudes of the compound muscle action potential (CMAP), a decrement in CMAP to low frequency nerve stimulation, an increment on high frequency stimulation and posttetanic facilitation over 300%. Following administration of prednisolone, these electrophysiological parameters became almost normal. This case suggests that immunosuppressive drugs such as prednisolone may have a place in the management of the patients with myasthenic syndrome, especially of those who has no evidence of malignant tumor.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalThe Tohoku Journal of Experimental Medicine
Issue number4
StatePublished - Jan 1984


  • Eaton-Lambert syndrome
  • electrodiagnosis
  • myasthenic syndrome
  • neuromuscular transmission

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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