The Ductus Debate: Ligation in Prematurity?

Willis H. Williams, Henry Gelband, Eduardo Bancalari, Charles Bauer, Otto Garcia, Dolores F. Tamer, Gerard A. Kaiser

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This report describes 20 premature infants who have undergone surgical ligation of a patent ductus arteriosus (PDA), diagnosed solely by physical examination in all but 2 instances. There were no operative deaths. Eleven of these 20 infants had severe associated hyaline membrane disease (HMD) necessitating mechanical ventilatory support from the first or second day of life. Only 3 of these 11 infants (27%) ultimately survived to leave the hospital. In contrast, 8 of 9 premature neonates (89%) with severe congestive heart failure but without HMD were discharged alive. Surgical ligation of the PDA in a premature infant is an appropriate and successful mode of treatment when congestive heart failure is refractory to medical management. Proof is lacking, however, to establish the efficacy of PDA ligation in the premature infant with HMD.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalAnnals of Thoracic Surgery
Issue number2
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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