The Ductus Debate: Ligation in Prematurity?

Willis H. Williams; Henry Gelband; Eduardo Bancalari; Charles Bauer; Otto Garcia; Dolores F. Tamer; Gerard A. Kaiser

doi:10.1016/S0003-4975(10)63977-X

The Ductus Debate: Ligation in Prematurity?

Willis H. Williams, Henry Gelband, Eduardo Bancalari, Charles Bauer, Otto Garcia, Dolores F. Tamer, Gerard A. Kaiser

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This report describes 20 premature infants who have undergone surgical ligation of a patent ductus arteriosus (PDA), diagnosed solely by physical examination in all but 2 instances. There were no operative deaths. Eleven of these 20 infants had severe associated hyaline membrane disease (HMD) necessitating mechanical ventilatory support from the first or second day of life. Only 3 of these 11 infants (27%) ultimately survived to leave the hospital. In contrast, 8 of 9 premature neonates (89%) with severe congestive heart failure but without HMD were discharged alive. Surgical ligation of the PDA in a premature infant is an appropriate and successful mode of treatment when congestive heart failure is refractory to medical management. Proof is lacking, however, to establish the efficacy of PDA ligation in the premature infant with HMD.

Original language	English (US)
Pages (from-to)	151-156
Number of pages	6
Journal	Annals of Thoracic Surgery
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/S0003-4975(10)63977-X
State	Published - Jan 1 1976

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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title = "The Ductus Debate: Ligation in Prematurity?",

abstract = "This report describes 20 premature infants who have undergone surgical ligation of a patent ductus arteriosus (PDA), diagnosed solely by physical examination in all but 2 instances. There were no operative deaths. Eleven of these 20 infants had severe associated hyaline membrane disease (HMD) necessitating mechanical ventilatory support from the first or second day of life. Only 3 of these 11 infants (27%) ultimately survived to leave the hospital. In contrast, 8 of 9 premature neonates (89%) with severe congestive heart failure but without HMD were discharged alive. Surgical ligation of the PDA in a premature infant is an appropriate and successful mode of treatment when congestive heart failure is refractory to medical management. Proof is lacking, however, to establish the efficacy of PDA ligation in the premature infant with HMD.",

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