The double blind study comparing disease to placebo: An editorial comment

Mark D. Brown, Robert B. Daroff

Research output: Contribution to journalArticle

18 Scopus citations


The authors participated in a double blind study on the effectiveness of chymopapain in the treatment of intervertebral disc disease. Results of the double blind study indicated that chymopapain was no more effective than a placebo. The authors challenge the validity of the double blind study because of timing of result evaluation, possible therapeutic activities of the placebo utilized, and possible insufficient dose of chymopapain.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
Issue number3
StatePublished - Sep 1977



  • Chemonucleolysis
  • Chymopapain
  • Low back pain

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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