The DISCUSS project: Induced pluripotent stem cell lines from previously collected research biospecimens and informed consent: Points to consider

Geoffrey P. Lomax, Sara Chandros Hull, Justin Lowenthal, Mahendra Rao, Rosario Isasi

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Human somatic cell reprogramming is a leading technology for accelerating disease modeling and drug discovery. Research organizations are sponsoring initiatives to create libraries of induced pluripotent stem cell (iPSC) lines for broad distribution and application. Donor informed consent plays a critical role in supporting the ethical conduct of iPSC research. To date, our organizations have focused on informed consent considerations for somatic cell collection intended specifically for iPSC derivation and distribution. This article considers how somatic cells obtained under general (biomedical) research protocols can be used for iPSC derivation. We present draft Points to Consider regarding the use of human somatic cells for iPSC research. Our goal is to initiate a process designed to develop consensus for the use of previously collected specimens for iPSC research. We anticipate publishing final considerations in early 2014.

Original languageEnglish (US)
Pages (from-to)727-730
Number of pages4
JournalStem Cells Translational Medicine
Volume2
Issue number10
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The DISCUSS project: Induced pluripotent stem cell lines from previously collected research biospecimens and informed consent: Points to consider'. Together they form a unique fingerprint.

  • Cite this