The diagnostic utility of anterior chamber paracentesis with polymerase chain reaction in anterior uveitis.

Zane Anwar, Anat Galor, Thomas A Albini, Darlene Miller, Victor L Perez Quinones, Janet L Davis

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To determine the value of anterior chamber paracentesis with polymerase chain reaction (PCR) in patients with anterior uveitis. Retrospective observational case series. Bascom Palmer Eye Institute. Fifty-three patients with a diagnosis of anterior uveitis who underwent anterior chamber paracentesis with PCR. Anterior chamber paracentesis with PCR of aqueous fluid. Diagnostic utility and frequency of management change based on anterior chamber paracentesis and PCR. There were 15 of 53 (28%) acute and 35 of 53 (65%) chronic anterior uveitis patients. PCR positivity of herpes simplex virus, cytomegalovirus, varicella zoster virus, and Epstein-Barr virus in our population were 4 of 53 (8%), 1 of 47 (2%), 1 of 35 (3%), and 1 of 18 (6%). Overall, 7 of 53 patients (13%) had a change in management because of PCR results from anterior chamber paracentesis. Four patients encountered paracentesis complications (4/53, 7.5%), 1 with long-term sequelae. Anterior chamber paracentesis with PCR had a relatively low diagnostic utility and resulted in few management changes in patients with suspected infectious anterior uveitis.

Original languageEnglish (US)
Pages (from-to)781-786
Number of pages6
JournalUnknown Journal
Volume155
Issue number5
StatePublished - 2013
Externally publishedYes

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Anterior Uveitis
Paracentesis
polymerase chain reaction
Polymerase chain reaction
Anterior Chamber
chambers
Polymerase Chain Reaction
viruses
Viruses
Human Herpesvirus 3
Simplexvirus
Cytomegalovirus
Human Herpesvirus 4
Fluids
fluids

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The diagnostic utility of anterior chamber paracentesis with polymerase chain reaction in anterior uveitis. / Anwar, Zane; Galor, Anat; Albini, Thomas A; Miller, Darlene; Perez Quinones, Victor L; Davis, Janet L.

In: Unknown Journal, Vol. 155, No. 5, 2013, p. 781-786.

Research output: Contribution to journalArticle

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