The diagnosis of major depression in patients with cancer: A comparative approach

Ying Guo, Dominique Musselman, Amita K. Manatunga, Natalie Gilles, Kathryn C. Lawson, Maryfrances R. Porter, J. Stephen McDaniel, Charles Nemeroff

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Depressive symptoms not only impair quality of life in cancer patients but constitute an independent risk factor for increased mortality. In order to accurately and efficiently identify depression in cancer patients, the authors developed a biostatistical strategy to identify items of the 21-item, observer-rated Hamilton Rating Scale for Depression (Ham-D) that would optimize the diagnosis of depression among cancer patients. Exhibiting a relatively high sensitivity and specificity, our most optimal diagnostic tool contained six Ham-D items (late insomnia, agitation, psychic anxiety, diurnal mood variation, depressed mood, and genital symptoms). This study may serve as a prototype to generate valid instruments accurate for the diagnosis of major depression in other populations of cancer patients.

Original languageEnglish
Pages (from-to)376-384
Number of pages9
JournalPsychosomatics
Volume47
Issue number5
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Fingerprint

Depression
Neoplasms
Sleep Initiation and Maintenance Disorders
Anxiety
Quality of Life
Cancer
Cancer Patients
Sensitivity and Specificity
Mortality
Population
Mood
Risk Factors
Observer
Specificity
Depressive Symptoms
Prototype
Diagnostics
Psychic
Rating Scales

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Psychology(all)

Cite this

The diagnosis of major depression in patients with cancer : A comparative approach. / Guo, Ying; Musselman, Dominique; Manatunga, Amita K.; Gilles, Natalie; Lawson, Kathryn C.; Porter, Maryfrances R.; McDaniel, J. Stephen; Nemeroff, Charles.

In: Psychosomatics, Vol. 47, No. 5, 01.10.2006, p. 376-384.

Research output: Contribution to journalArticle

Guo, Y, Musselman, D, Manatunga, AK, Gilles, N, Lawson, KC, Porter, MR, McDaniel, JS & Nemeroff, C 2006, 'The diagnosis of major depression in patients with cancer: A comparative approach', Psychosomatics, vol. 47, no. 5, pp. 376-384. https://doi.org/10.1176/appi.psy.47.5.376
Guo, Ying ; Musselman, Dominique ; Manatunga, Amita K. ; Gilles, Natalie ; Lawson, Kathryn C. ; Porter, Maryfrances R. ; McDaniel, J. Stephen ; Nemeroff, Charles. / The diagnosis of major depression in patients with cancer : A comparative approach. In: Psychosomatics. 2006 ; Vol. 47, No. 5. pp. 376-384.
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