The Diagnosis, Management, and Postnatal Prevention of Intraventricular Hemorrhage in the Preterm Neonate

Heather J. McCrea, Laura R. Ment

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

Intraventricular hemorrhage (IVH) occurs in 20% to 25% of very low birthweight preterm neonates and may be associated with significant sequelae. Infants who have IVH are at risk for posthemorrhagic hydrocephalus and periventricular leukomalacia; as many as 75% of those who have parenchymal involvement of hemorrhage suffer significant neurodevelopmental disability. Because of the prevalence of IVH and the medical and societal impact of this disease, many postnatal pharmacologic prevention strategies have been explored. Randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury, and pharmacologic intervention on the developing brain.

Original languageEnglish (US)
Pages (from-to)777-792
Number of pages16
JournalClinics in Perinatology
Volume35
Issue number4
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • Ibuprofen
  • Indomethacin
  • Intraventricular hemorrhage
  • Phenobarbital
  • Preterm
  • Prevention

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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