TY - JOUR
T1 - The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type 1
AU - Tian, Xinrong
AU - Hsin, Ling Wei
AU - Webster, Elizabeth L.
AU - Contoreggi, Carlo
AU - Chrousos, George P.
AU - Gold, Philip W.
AU - Habib, Kamal
AU - Ayala, Alejandro
AU - Eckelman, William C.
AU - Jacobson, Arthur E.
AU - Rice, Kenner C.
PY - 2001/2/12
Y1 - 2001/2/12
N2 - A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylp yrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3.
AB - A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylp yrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3.
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U2 - 10.1016/S0960-894X(00)00661-2
DO - 10.1016/S0960-894X(00)00661-2
M3 - Article
C2 - 11212103
AN - SCOPUS:0035847696
VL - 11
SP - 331
EP - 333
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -