The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation

M. C.C. Canesso, L. Lemos, T. C. Neves, F. M. Marim, T. B.R. Castro, És Veloso, C. P. Queiroz, J. Ahn, H. C. Santiago, F. S. Martins, J. Alves-Silva, E. Ferreira, D. C. Cara, A. T. Vieira, G. N. Barber, S. C. Oliveira, A. M.C. Faria

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


STING (stimulator of interferon genes) is a cytosolic sensor for cyclic dinucleotides and also an adaptor molecule for intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and in autoimmune diseases, its physiological relevance in intestinal homeostasis is largely unknown. In this study, we show that STING '/' mice presented defective protective mechanisms of intestinal mucosa, including decreased number of goblet cells, diminished mucus production, and lower levels of secretory IgA, when compared with wild-type (WT) mice. Fecal content and microbiota DNA could activate STING, indicating a role of this molecule in gut. Microbiota composition was altered in STING '/' mice toward a more inflammatory profile, evidencing a reduction in the Allobacolum and Bifidobacterium groups along with increase in Disulfovibrio bacteria. Absence of STING lead to decrease in induced intraepithelial lymphocytes (IEL) and to increase in group 1 innate lymphoid cell (ILC1) as well as ILC3 frequencies and decrease in ILC2 in the colon. Development and function of Foxp3+ and LAP+ regulatory T cells were also compromised in STING '/' mice. Moreover, these mice were highly susceptible to dextran sodium sulfate-induced colitis, T-cell-induced colitis, and enteric Salmonella typhimurium infection when compared with WT animals. Therefore, our results identify an important role of STING in maintaining gut homeostasis and also a protective effect in controlling gut inflammation.

Original languageEnglish (US)
Pages (from-to)820-834
Number of pages15
JournalMucosal Immunology
Issue number3
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation'. Together they form a unique fingerprint.

Cite this