The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease

Laila Abdullah, Ghania Ait-Ghezala, Fiona Crawford, Timothy A. Crowell, Warren W. Barker, Ranjan Duara, Michael Mullan

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The cyclooxygenase-2 enzyme (COX-2) is of particular importance in the inflammatory response and recent findings have demonstrated a considerable role in Alzheimer's disease (AD) pathogenesis. In order to assess the possible putative role of a COX-2 polymorphism (765 G/C) in AD, we examined its distribution in 161 community-based controls and 168 AD clinic-based cases previously recruited from memory disorder clinics in Tampa and Miami, Florida. There were no significant differences between the two groups in age/age of onset or gender. A significant difference was observed in the distribution of the COX-2 -765 alleles between AD cases and controls (χ2 = 6.565, p = .010; OR = .596; CI = [.401-.888], p = .011), with the frequency of the C allele being higher in controls. In addition, a significant difference was observed for this polymorphism by genotype (χ2 = 6.561, p = .038) and by presence or absence of C+ genotypes (χ2 = 6.207, p = .013; OR = .464, CI = [.351-.885], p = .013). In this sample, the C allele of COX-2 -765 promoter polymorphism is associated with decreased risk of Alzheimer's disease, a finding which further supports the involvement of COX-2 in AD etiology.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalNeuroscience Letters
Volume395
Issue number3
DOIs
StatePublished - Mar 13 2006
Externally publishedYes

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Cyclooxygenase 2
Alzheimer Disease
Alleles
Enzymes
Genotype
Memory Disorders
Age of Onset
Gene Frequency
Protective Factors
Age Groups

Keywords

  • Alzheimer's disease cyclooxygenase 2
  • Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abdullah, L., Ait-Ghezala, G., Crawford, F., Crowell, T. A., Barker, W. W., Duara, R., & Mullan, M. (2006). The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease. Neuroscience Letters, 395(3), 240-243. https://doi.org/10.1016/j.neulet.2005.10.090

The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease. / Abdullah, Laila; Ait-Ghezala, Ghania; Crawford, Fiona; Crowell, Timothy A.; Barker, Warren W.; Duara, Ranjan; Mullan, Michael.

In: Neuroscience Letters, Vol. 395, No. 3, 13.03.2006, p. 240-243.

Research output: Contribution to journalArticle

Abdullah, L, Ait-Ghezala, G, Crawford, F, Crowell, TA, Barker, WW, Duara, R & Mullan, M 2006, 'The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease', Neuroscience Letters, vol. 395, no. 3, pp. 240-243. https://doi.org/10.1016/j.neulet.2005.10.090
Abdullah L, Ait-Ghezala G, Crawford F, Crowell TA, Barker WW, Duara R et al. The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease. Neuroscience Letters. 2006 Mar 13;395(3):240-243. https://doi.org/10.1016/j.neulet.2005.10.090
Abdullah, Laila ; Ait-Ghezala, Ghania ; Crawford, Fiona ; Crowell, Timothy A. ; Barker, Warren W. ; Duara, Ranjan ; Mullan, Michael. / The cyclooxygenase 2-765 C promoter allele is a protective factor for Alzheimer's disease. In: Neuroscience Letters. 2006 ; Vol. 395, No. 3. pp. 240-243.
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