The cure of cancer: A European perspective

The EUROCARE Working Group

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Cancer survival analyses based on cancer registry data do not provide direct information on the main aim of cancer treatment, the cure of the patient. In fact, classic survival indicators do not distinguish between patients who are cured, and patients who will die of their disease and in whom prolongation of survival is the main objective of treatment. In this study, we applied parametric curemodels to the cancer incidence and follow-up data provided by 49 EUROCARE-4 (European Cancer Registry-based study, fourth edition) cancer registries, with the aims of providing additional insights into the survival of European cancer patients diagnosed from 1988 to 1999, and of investigating between-population differences. Between-country estimates the proportion of cured patients varied fromabout 4-13%for lung cancer, from9% to 30% for stomach cancer, from25% to 49% for colon and rectumcancer, and from55%to 73%for breast cancer. For all cancers combined, estimates varied between 21%and 47% in men, and 38% and 59% in women and were influenced by the distribution of cases by cancer site. Countries with high proportions of cured and long fatal case survival times for all cancers combined were characterised by generally favourable case mix. For the European pool of cases both the proportion of cured and the survival time of fatal cases were associated with age, and increased fromthe early to the latest diagnosis period. The increases over time in the proportions of Europeans estimated cured of lung, stomach and colon and rectumcancers are noteworthy and suggest genuine progress in cancer control. The proportion of cured of all cancers combined is a useful general indicator of cancer control as it reflects progress in diagnosis and treatment, as well as success in the prevention of rapidly fatal cancers.

Original languageEnglish (US)
Pages (from-to)1067-1079
Number of pages13
JournalEuropean Journal of Cancer
Volume45
Issue number6
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Neoplasms
Survival
Registries
Colon
Diagnosis-Related Groups
Delayed Diagnosis
Survival Analysis
Stomach Neoplasms
Lung Neoplasms
Stomach
Therapeutics
Breast Neoplasms
Lung
Incidence
Population

Keywords

  • Breast cancer
  • Colon and rectum cancer
  • Cure
  • Lung cancer
  • Prostate cancer
  • Relative survival
  • Statistical models
  • Stomach cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The cure of cancer : A European perspective. / The EUROCARE Working Group.

In: European Journal of Cancer, Vol. 45, No. 6, 01.04.2009, p. 1067-1079.

Research output: Contribution to journalArticle

The EUROCARE Working Group. / The cure of cancer : A European perspective. In: European Journal of Cancer. 2009 ; Vol. 45, No. 6. pp. 1067-1079.
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AU - Santaquilani, Mariano

AU - Simonetti, Arianna

AU - Allemani, Claudia

AU - Gatta, Gemma

AU - Sant, Milena

AU - Zigon, Giulia

AU - Bray, Freddie

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AU - Tron, I.

AU - Le Gall, E.

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AU - Guizard, A. V.

AU - Faivre, J.

AU - Bouvier, A. M.

AU - Carli, P. M.

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KW - Colon and rectum cancer

KW - Cure

KW - Lung cancer

KW - Prostate cancer

KW - Relative survival

KW - Statistical models

KW - Stomach cancer

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