The CRF system, stress, depression and anxietyinsights from human genetic studies

E. B. Binder, Charles Nemeroff

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. Recently, human genetic studies have provided considerable support to several long-standing hypotheses of mood and anxiety disorders, including the CRF hypothesis. These data, reviewed in this report, are congruent with the hypothesis that this system is of paramount importance in mediating stress-related psychopathology. More specifically, variants in the gene encoding the CRF 1 receptor interact with adverse environmental factors to predict risk for stress-related psychiatric disorders. In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience.

Original languageEnglish
Pages (from-to)574-588
Number of pages15
JournalMolecular Psychiatry
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Corticotropin-Releasing Hormone
Medical Genetics
Depression
Anxiety Disorders
Psychopathology
Mood Disorders
Psychiatry
Anxiety
Genes
Clinical Studies
CRF receptor type 1

Keywords

  • Anxiety
  • CRF
  • CRH
  • Depression
  • Genetic
  • Receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

The CRF system, stress, depression and anxietyinsights from human genetic studies. / Binder, E. B.; Nemeroff, Charles.

In: Molecular Psychiatry, Vol. 15, No. 6, 01.06.2010, p. 574-588.

Research output: Contribution to journalArticle

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