The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

Mark A. Smith, Jonathan Davidson, James C. Ritchie, Harold Kudler, Stephen Lipper, Phillip Chappell, Charles Nemeroff

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

To evaluate the hypothalamic-pituitary-adrenal (HPA) axis in patients with posttraumatic stress disorder (PTSD), we measured adrenocorticotropin hormone (ACTH) and cortisol responses following administration of corticotropin-releasing hormone (CRH) in 8 combat veterans with chronic PTSD. The PTSD patients had a significantly lower ACTH response to CRH compared to a control group of normal volunteers. Blunted ACTH responses occurred in patients with PTSD alone, as well as those PTSD patients who also had major depression. The cortisol response, although reduced, was not significantly different from normal. The blunted ACTH response to CRH in PTSD patients is similar to that seen in other psychiatric disorders, such as depression, panic disorder, and anorexia nervosa.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalBiological Psychiatry
Volume26
Issue number4
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Corticotropin-Releasing Hormone
Post-Traumatic Stress Disorders
Adrenocorticotropic Hormone
Hormones
Hydrocortisone
Depression
Panic Disorder
Anorexia Nervosa
Veterans
Psychiatry
Healthy Volunteers
Control Groups

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. / Smith, Mark A.; Davidson, Jonathan; Ritchie, James C.; Kudler, Harold; Lipper, Stephen; Chappell, Phillip; Nemeroff, Charles.

In: Biological Psychiatry, Vol. 26, No. 4, 01.01.1989, p. 349-355.

Research output: Contribution to journalArticle

Smith, MA, Davidson, J, Ritchie, JC, Kudler, H, Lipper, S, Chappell, P & Nemeroff, C 1989, 'The corticotropin-releasing hormone test in patients with posttraumatic stress disorder', Biological Psychiatry, vol. 26, no. 4, pp. 349-355. https://doi.org/10.1016/0006-3223(89)90050-4
Smith MA, Davidson J, Ritchie JC, Kudler H, Lipper S, Chappell P et al. The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biological Psychiatry. 1989 Jan 1;26(4):349-355. https://doi.org/10.1016/0006-3223(89)90050-4
Smith, Mark A. ; Davidson, Jonathan ; Ritchie, James C. ; Kudler, Harold ; Lipper, Stephen ; Chappell, Phillip ; Nemeroff, Charles. / The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. In: Biological Psychiatry. 1989 ; Vol. 26, No. 4. pp. 349-355.
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