The corticotropin releasing factor stimulation test in patients with major depression

Relationship to dexamethasone suppression test results

K. Ranga R Krishnan, Krishnaiah Rayasam, Deborah Reed, Mark Smith, Phillip Chapell, William B. Saunders, James C. Ritchie, Bernard J. Carroll, Charles Nemeroff

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the relationship between these two abnormalities. Twenty‐three depressed patients and eighteen control subjects received both a standard CRF stimulation test and the dexamethasone suppression test (DST). Nonsuppressors on the DST exhibited a blunted ACTH response to CRF; DST suppressors exhibited a normal ACTH response to CRF. This suggests that the two abnormalities of the hypothalamic‐pituitary‐adrenal (HPA) axis are related and may be due to similar pathopbysiological mechanisms. Depression 1:133–136 (1993). © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalDepression
Volume1
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Dexamethasone
Adrenocorticotropic Hormone
Hydrocortisone

Keywords

  • CRF stimulation test
  • dexamethasone suppression test
  • hypothalamic‐pituitary‐adrenal axis abnormalities

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The corticotropin releasing factor stimulation test in patients with major depression : Relationship to dexamethasone suppression test results. / Krishnan, K. Ranga R; Rayasam, Krishnaiah; Reed, Deborah; Smith, Mark; Chapell, Phillip; Saunders, William B.; Ritchie, James C.; Carroll, Bernard J.; Nemeroff, Charles.

In: Depression, Vol. 1, No. 3, 1993, p. 133-136.

Research output: Contribution to journalArticle

Krishnan, KRR, Rayasam, K, Reed, D, Smith, M, Chapell, P, Saunders, WB, Ritchie, JC, Carroll, BJ & Nemeroff, C 1993, 'The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results', Depression, vol. 1, no. 3, pp. 133-136. https://doi.org/10.1002/depr.3050010303
Krishnan, K. Ranga R ; Rayasam, Krishnaiah ; Reed, Deborah ; Smith, Mark ; Chapell, Phillip ; Saunders, William B. ; Ritchie, James C. ; Carroll, Bernard J. ; Nemeroff, Charles. / The corticotropin releasing factor stimulation test in patients with major depression : Relationship to dexamethasone suppression test results. In: Depression. 1993 ; Vol. 1, No. 3. pp. 133-136.
@article{57b4996aac094b7aa69025e1837cfd62,
title = "The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results",
abstract = "Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the relationship between these two abnormalities. Twenty‐three depressed patients and eighteen control subjects received both a standard CRF stimulation test and the dexamethasone suppression test (DST). Nonsuppressors on the DST exhibited a blunted ACTH response to CRF; DST suppressors exhibited a normal ACTH response to CRF. This suggests that the two abnormalities of the hypothalamic‐pituitary‐adrenal (HPA) axis are related and may be due to similar pathopbysiological mechanisms. Depression 1:133–136 (1993). {\circledC} 1993 Wiley‐Liss, Inc.",
keywords = "CRF stimulation test, dexamethasone suppression test, hypothalamic‐pituitary‐adrenal axis abnormalities",
author = "Krishnan, {K. Ranga R} and Krishnaiah Rayasam and Deborah Reed and Mark Smith and Phillip Chapell and Saunders, {William B.} and Ritchie, {James C.} and Carroll, {Bernard J.} and Charles Nemeroff",
year = "1993",
doi = "10.1002/depr.3050010303",
language = "English (US)",
volume = "1",
pages = "133--136",
journal = "Depression",
issn = "1062-6417",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - The corticotropin releasing factor stimulation test in patients with major depression

T2 - Relationship to dexamethasone suppression test results

AU - Krishnan, K. Ranga R

AU - Rayasam, Krishnaiah

AU - Reed, Deborah

AU - Smith, Mark

AU - Chapell, Phillip

AU - Saunders, William B.

AU - Ritchie, James C.

AU - Carroll, Bernard J.

AU - Nemeroff, Charles

PY - 1993

Y1 - 1993

N2 - Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the relationship between these two abnormalities. Twenty‐three depressed patients and eighteen control subjects received both a standard CRF stimulation test and the dexamethasone suppression test (DST). Nonsuppressors on the DST exhibited a blunted ACTH response to CRF; DST suppressors exhibited a normal ACTH response to CRF. This suggests that the two abnormalities of the hypothalamic‐pituitary‐adrenal (HPA) axis are related and may be due to similar pathopbysiological mechanisms. Depression 1:133–136 (1993). © 1993 Wiley‐Liss, Inc.

AB - Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the relationship between these two abnormalities. Twenty‐three depressed patients and eighteen control subjects received both a standard CRF stimulation test and the dexamethasone suppression test (DST). Nonsuppressors on the DST exhibited a blunted ACTH response to CRF; DST suppressors exhibited a normal ACTH response to CRF. This suggests that the two abnormalities of the hypothalamic‐pituitary‐adrenal (HPA) axis are related and may be due to similar pathopbysiological mechanisms. Depression 1:133–136 (1993). © 1993 Wiley‐Liss, Inc.

KW - CRF stimulation test

KW - dexamethasone suppression test

KW - hypothalamic‐pituitary‐adrenal axis abnormalities

UR - http://www.scopus.com/inward/record.url?scp=85005304960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005304960&partnerID=8YFLogxK

U2 - 10.1002/depr.3050010303

DO - 10.1002/depr.3050010303

M3 - Article

VL - 1

SP - 133

EP - 136

JO - Depression

JF - Depression

SN - 1062-6417

IS - 3

ER -