The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results

K. Ranga R Krishnan, Krishnaiah Rayasam, Deborah Reed, Mark Smith, Phillip Chapell, William B. Saunders, James C. Ritchie, Bernard J. Carroll, Charles Nemeroff

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the relationship between these two abnormalities. Twenty‐three depressed patients and eighteen control subjects received both a standard CRF stimulation test and the dexamethasone suppression test (DST). Nonsuppressors on the DST exhibited a blunted ACTH response to CRF; DST suppressors exhibited a normal ACTH response to CRF. This suggests that the two abnormalities of the hypothalamic‐pituitary‐adrenal (HPA) axis are related and may be due to similar pathopbysiological mechanisms. Depression 1:133–136 (1993). © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalDepression
Volume1
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

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Keywords

  • CRF stimulation test
  • dexamethasone suppression test
  • hypothalamic‐pituitary‐adrenal axis abnormalities

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Krishnan, K. R. R., Rayasam, K., Reed, D., Smith, M., Chapell, P., Saunders, W. B., Ritchie, J. C., Carroll, B. J., & Nemeroff, C. (1993). The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results. Depression, 1(3), 133-136. https://doi.org/10.1002/depr.3050010303