The contrast media iohexol causes vasoconstriction of the proximal left anterior descending coronary artery: Implications for appropriate stent sizing

Robert V. Kelly, Michael J. Gillespie, Mauricio G Cohen, David P. McLaughlin, E. Magnus Ohman, George A. Stouffer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of the contrast agent iohexol on reference vessel size in patients with proximal left anterior descending disease is unknown. Quantitative coronary angiography and intravascular ultrasound were performed in 15 patients with atherosclerotic disease of the proximal left anterior descending. Mean proximal reference vessel diameter was 2.95 ± 0.59 mm with quantitative coronary angiography and 4.65 ± 0.66 mm with intravascular ultrasound (P <.05). Intracoronary injection of iohexol resulted in a significant decrease in intravascular ultrasound-measured proximal reference vessel diameter from 4.65 ± 0.66 mm to 4.47 ± 0.68 mm (P =.002). Vasoconstrictive response to iohexol in the proximal reference vessel ranged from -0.04 mm to 0.5 mm with a mean of 0.18 ± 0.16 mm. This study shows that iohexol can cause significant vasoconstriction of the proximal reference vessel in patients with severe disease involving the proximal left anterior descending.

Original languageEnglish
Pages (from-to)574-580
Number of pages7
JournalAngiology
Volume59
Issue number5
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Fingerprint

Iohexol
Vasoconstriction
Contrast Media
Stents
Coronary Vessels
Coronary Angiography
Injections

Keywords

  • Contrast media
  • Left anterior descending coronary artery
  • Stent
  • Vasoconstriction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The contrast media iohexol causes vasoconstriction of the proximal left anterior descending coronary artery : Implications for appropriate stent sizing. / Kelly, Robert V.; Gillespie, Michael J.; Cohen, Mauricio G; McLaughlin, David P.; Magnus Ohman, E.; Stouffer, George A.

In: Angiology, Vol. 59, No. 5, 01.10.2008, p. 574-580.

Research output: Contribution to journalArticle

Kelly, Robert V. ; Gillespie, Michael J. ; Cohen, Mauricio G ; McLaughlin, David P. ; Magnus Ohman, E. ; Stouffer, George A. / The contrast media iohexol causes vasoconstriction of the proximal left anterior descending coronary artery : Implications for appropriate stent sizing. In: Angiology. 2008 ; Vol. 59, No. 5. pp. 574-580.
@article{68201c1896b8407b8edb3ba3a82b4d44,
title = "The contrast media iohexol causes vasoconstriction of the proximal left anterior descending coronary artery: Implications for appropriate stent sizing",
abstract = "The effect of the contrast agent iohexol on reference vessel size in patients with proximal left anterior descending disease is unknown. Quantitative coronary angiography and intravascular ultrasound were performed in 15 patients with atherosclerotic disease of the proximal left anterior descending. Mean proximal reference vessel diameter was 2.95 ± 0.59 mm with quantitative coronary angiography and 4.65 ± 0.66 mm with intravascular ultrasound (P <.05). Intracoronary injection of iohexol resulted in a significant decrease in intravascular ultrasound-measured proximal reference vessel diameter from 4.65 ± 0.66 mm to 4.47 ± 0.68 mm (P =.002). Vasoconstrictive response to iohexol in the proximal reference vessel ranged from -0.04 mm to 0.5 mm with a mean of 0.18 ± 0.16 mm. This study shows that iohexol can cause significant vasoconstriction of the proximal reference vessel in patients with severe disease involving the proximal left anterior descending.",
keywords = "Contrast media, Left anterior descending coronary artery, Stent, Vasoconstriction",
author = "Kelly, {Robert V.} and Gillespie, {Michael J.} and Cohen, {Mauricio G} and McLaughlin, {David P.} and {Magnus Ohman}, E. and Stouffer, {George A.}",
year = "2008",
month = "10",
day = "1",
doi = "10.1177/0003319708318375",
language = "English",
volume = "59",
pages = "574--580",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - The contrast media iohexol causes vasoconstriction of the proximal left anterior descending coronary artery

T2 - Implications for appropriate stent sizing

AU - Kelly, Robert V.

AU - Gillespie, Michael J.

AU - Cohen, Mauricio G

AU - McLaughlin, David P.

AU - Magnus Ohman, E.

AU - Stouffer, George A.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - The effect of the contrast agent iohexol on reference vessel size in patients with proximal left anterior descending disease is unknown. Quantitative coronary angiography and intravascular ultrasound were performed in 15 patients with atherosclerotic disease of the proximal left anterior descending. Mean proximal reference vessel diameter was 2.95 ± 0.59 mm with quantitative coronary angiography and 4.65 ± 0.66 mm with intravascular ultrasound (P <.05). Intracoronary injection of iohexol resulted in a significant decrease in intravascular ultrasound-measured proximal reference vessel diameter from 4.65 ± 0.66 mm to 4.47 ± 0.68 mm (P =.002). Vasoconstrictive response to iohexol in the proximal reference vessel ranged from -0.04 mm to 0.5 mm with a mean of 0.18 ± 0.16 mm. This study shows that iohexol can cause significant vasoconstriction of the proximal reference vessel in patients with severe disease involving the proximal left anterior descending.

AB - The effect of the contrast agent iohexol on reference vessel size in patients with proximal left anterior descending disease is unknown. Quantitative coronary angiography and intravascular ultrasound were performed in 15 patients with atherosclerotic disease of the proximal left anterior descending. Mean proximal reference vessel diameter was 2.95 ± 0.59 mm with quantitative coronary angiography and 4.65 ± 0.66 mm with intravascular ultrasound (P <.05). Intracoronary injection of iohexol resulted in a significant decrease in intravascular ultrasound-measured proximal reference vessel diameter from 4.65 ± 0.66 mm to 4.47 ± 0.68 mm (P =.002). Vasoconstrictive response to iohexol in the proximal reference vessel ranged from -0.04 mm to 0.5 mm with a mean of 0.18 ± 0.16 mm. This study shows that iohexol can cause significant vasoconstriction of the proximal reference vessel in patients with severe disease involving the proximal left anterior descending.

KW - Contrast media

KW - Left anterior descending coronary artery

KW - Stent

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=53949112643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53949112643&partnerID=8YFLogxK

U2 - 10.1177/0003319708318375

DO - 10.1177/0003319708318375

M3 - Article

C2 - 18505744

AN - SCOPUS:53949112643

VL - 59

SP - 574

EP - 580

JO - Angiology

JF - Angiology

SN - 0003-3197

IS - 5

ER -