The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Warren D. Taylor, Stephan Züchner, Martha E. Payne, Denise F. Messer, Tracy J. Doty, James R. MacFall, John L. Beyer, K. Ranga R. Krishnan

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume155
Issue number2
DOIs
StatePublished - Jul 15 2007

Keywords

  • Genetic polymorphisms
  • Hippocampus
  • Magnetic resonance imaging
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Fingerprint Dive into the research topics of 'The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults'. Together they form a unique fingerprint.

  • Cite this

    Taylor, W. D., Züchner, S., Payne, M. E., Messer, D. F., Doty, T. J., MacFall, J. R., Beyer, J. L., & Krishnan, K. R. R. (2007). The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. Psychiatry Research - Neuroimaging, 155(2), 173-177. https://doi.org/10.1016/j.pscychresns.2007.01.005