The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Warren D. Taylor, Stephan L Zuchner, Martha E. Payne, Denise F. Messer, Tracy J. Doty, James R. MacFall, John L. Beyer, K. Ranga R Krishnan

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume155
Issue number2
DOIs
StatePublished - Jul 15 2007
Externally publishedYes

Fingerprint

Temporal Lobe
Homozygote
Amygdala
Healthy Volunteers
Alleles
Genotype
Demography
Brain

Keywords

  • Genetic polymorphisms
  • Hippocampus
  • Magnetic resonance imaging
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Taylor, W. D., Zuchner, S. L., Payne, M. E., Messer, D. F., Doty, T. J., MacFall, J. R., ... Krishnan, K. R. R. (2007). The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. Psychiatry Research - Neuroimaging, 155(2), 173-177. https://doi.org/10.1016/j.pscychresns.2007.01.005

The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. / Taylor, Warren D.; Zuchner, Stephan L; Payne, Martha E.; Messer, Denise F.; Doty, Tracy J.; MacFall, James R.; Beyer, John L.; Krishnan, K. Ranga R.

In: Psychiatry Research - Neuroimaging, Vol. 155, No. 2, 15.07.2007, p. 173-177.

Research output: Contribution to journalArticle

Taylor, WD, Zuchner, SL, Payne, ME, Messer, DF, Doty, TJ, MacFall, JR, Beyer, JL & Krishnan, KRR 2007, 'The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults', Psychiatry Research - Neuroimaging, vol. 155, no. 2, pp. 173-177. https://doi.org/10.1016/j.pscychresns.2007.01.005
Taylor, Warren D. ; Zuchner, Stephan L ; Payne, Martha E. ; Messer, Denise F. ; Doty, Tracy J. ; MacFall, James R. ; Beyer, John L. ; Krishnan, K. Ranga R. / The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. In: Psychiatry Research - Neuroimaging. 2007 ; Vol. 155, No. 2. pp. 173-177.
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