The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

Dean A. Regier; Ronald C. Desrosiers

doi:10.1089/aid.1990.6.1221

The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

Dean A. Regier, Ronald C. Desrosiers

Research output: Contribution to journal › Article

304 Scopus citations

Abstract

The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIV_mac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIV_mac239 is closely related to SIV_mac251 (98%) and SIV_macl42 (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.

Original language	English (US)
Pages (from-to)	1221-1231
Number of pages	11
Journal	AIDS research and human retroviruses
Volume	6
Issue number	11
DOIs	https://doi.org/10.1089/aid.1990.6.1221
State	Published - Nov 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.1990.6.1221

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Regier, D. A., & Desrosiers, R. C. (1990). The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus. AIDS research and human retroviruses, 6(11), 1221-1231. https://doi.org/10.1089/aid.1990.6.1221

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