The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIV(mac239), has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIV(mac239) is closely related to SIV(mac251) (98%) and SIV(mac142) (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.

Original languageEnglish (US)
Pages (from-to)1221-1231
Number of pages11
JournalAIDS Research and Human Retroviruses
Volume6
Issue number11
StatePublished - 1990
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
nef Genes
Clone Cells
Terminal Repeat Sequences
Macaca
Macaca mulatta
Codon
Base Pairing
Open Reading Frames
Nucleotides
Genome
Viruses

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. / Regier, D. A.; Desrosiers, Ronald Charles.

In: AIDS Research and Human Retroviruses, Vol. 6, No. 11, 1990, p. 1221-1231.

Research output: Contribution to journalArticle

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