The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

Dean A. Regier, Ronald C. Desrosiers

Research output: Contribution to journalArticle

304 Scopus citations

Abstract

The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIVmac239 is closely related to SIVmac251 (98%) and SIVmacl42 (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.

Original languageEnglish (US)
Pages (from-to)1221-1231
Number of pages11
JournalAIDS research and human retroviruses
Volume6
Issue number11
DOIs
StatePublished - Nov 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus'. Together they form a unique fingerprint.

  • Cite this