TY - JOUR
T1 - The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus
AU - Regier, Dean A.
AU - Desrosiers, Ronald C.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990/11
Y1 - 1990/11
N2 - The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIVmac239 is closely related to SIVmac251 (98%) and SIVmacl42 (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.
AB - The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIVmac239 is closely related to SIVmac251 (98%) and SIVmacl42 (96%). It will now be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.
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U2 - 10.1089/aid.1990.6.1221
DO - 10.1089/aid.1990.6.1221
M3 - Article
C2 - 2078405
AN - SCOPUS:0025222481
VL - 6
SP - 1221
EP - 1231
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 11
ER -
