The complement cascade: New avenues in stroke therapy

Ricardo J. Komotar, Robert M. Starke, Eric J. Arias, Matthew C. Garrett, Marc L. Otten, Maxwell B. Merkow, Benjamin Hassid, J. Mocco, Michael E. Sughrue, Grace H. Kim, William J. Mack, Andrew F. Ducruet, E. Sander Connolly

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the exact mechanism of this secondary injury is unclear, several experimental studies have indicated an intimate connection between complement and this secondary form of damage. We review the available literature and attempt to identify promising clinical therapeutic targets.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalCurrent Vascular Pharmacology
Volume7
Issue number3
DOIs
StatePublished - Oct 9 2009
Externally publishedYes

    Fingerprint

Keywords

  • Complement
  • Ischemia
  • Reperfusion
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Komotar, R. J., Starke, R. M., Arias, E. J., Garrett, M. C., Otten, M. L., Merkow, M. B., Hassid, B., Mocco, J., Sughrue, M. E., Kim, G. H., Mack, W. J., Ducruet, A. F., & Connolly, E. S. (2009). The complement cascade: New avenues in stroke therapy. Current Vascular Pharmacology, 7(3), 287-292. https://doi.org/10.2174/157016109788340677