Communicating numerical estimates of cardiovascular risk (CVR) to patients encourage risk reduction actions. Avatars may enhance the risk messages ability to improve persuasion to adhere to healthy behaviors. We compared the efficacy of a computer-based aid communicating CVR with and without animated avatars for improving intention to adhere to lifestyle changes. Males with intermediate to high CVR received their risk message in 2 versions: an avatar using voice; voice only. Forty-one participants completed the study. Intent to change lifestyle showed a significant effect favoring the avatar (moderate effect size). Intent to follow medical treatments also showed a significant effect favoring the avatar (moderate effect size). An avatar-based computer aid significantly increased participants' intention to adhere to positive behavioral changes.