The clinical utility of lurasidone in schizophrenia: Patient considerations

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Lurasidone is a novel antipsychotic agent approved for the treatment of schizophrenia in a number of countries including the United Kingdom, other European countries, the United States, and Canada. In addition to full antagonist activity at the dopamine D2 (Ki, 1 nM) and serotonin 5-HT2A (Ki, 0.5 nM) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-HT7 receptors (0.5 nM) and its partial agonist activity at 5-HT1A receptors (Ki, 6.4 nM). Long-term treatment of schizophrenia with lurasidone has been shown to reduce the risk of relapse in patients with schizophrenia. Lurasidone appears to be associated with minimal effects on body weight, and low risk for clinically meaningful alterations in glucose, lipids, or electrocardiography parameters. Evidence from two randomized trials also suggests improvement in functional capacity and cognitive functioning in people with schizophrenia. A significant evidence base supports the use of lurasidone as a promising agent for the treatment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)1103-1109
Number of pages7
JournalNeuropsychiatric Disease and Treatment
Volume11
DOIs
StatePublished - Apr 28 2015

Keywords

  • Antagonist
  • Long-term treatment
  • Pharmacodynamic profile

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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