The clinical spectrum of renal disease associated with human immunodeficiency virus

J. J. Bourgoignie, R. Meneses, C. Ortiz, D. Jaffe, V. Pardo

Research output: Contribution to journalArticle

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Abstract

A nephrology consultation was called on 100 adult patients of 1,635 (6.1%) patients with human immunodeficiency virus (HIV) infection seen between 1982 and 1987 at the University of Miami/Jackson Memorial Medical Center. Renal disease was observed in all groups of patients with a risk factor for HIV infection with a lesser incidence, however, among homosexuals. Intravenous drug (IVD) use and possibly race appear to be important factors in the development of renal complications. Renal disease was the dominant clinical feature in eight asymptomatic HIV carriers and in 34 patients with AIDS-related complex (ARC) who had not developed the opportunistic infections and/or malignancies associated with acquired immunodeficiency syndrome (AIDS). Ninety-one percent of consultations were requested for evaluation of proteinuria and/or renal failure. Nephrotic range proteinuria, in excess of 3 g/24 h, was present in 52 patients, and was less prevalent in homosexuals than in other groups at risk. Renal failure (serum creatinine ≥ 5 mg/dL), initially present in 32 patients, eventually developed in 69 and improved in only 18 of them. A renal biopsy, obtained for work-up of nephrotic syndrome (22 patients) or renal insufficiency (3 patients), uncovered a picture of focal and segmental glomerulosclerosis in all 25 instances. Overall, 76 patients are dead, seven are lost to follow-up, and 17 are alive, of whom eight (four HIV carriers, two patients with ARC, and two with AIDS) are on maintenance hemodialysis with a mean survival time of 217 days.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume12
Issue number2
StatePublished - Jan 1 1988

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HIV
Kidney
Renal Insufficiency
Acquired Immunodeficiency Syndrome
Virus Diseases
Proteinuria
Referral and Consultation
AIDS-Related Complex
Focal Segmental Glomerulosclerosis
Nephrology
Lost to Follow-Up
Opportunistic Infections
Nephrotic Syndrome
Renal Dialysis
Creatinine
Survival Rate
Maintenance
Biopsy
Incidence
Serum

ASJC Scopus subject areas

  • Nephrology

Cite this

Bourgoignie, J. J., Meneses, R., Ortiz, C., Jaffe, D., & Pardo, V. (1988). The clinical spectrum of renal disease associated with human immunodeficiency virus. American Journal of Kidney Diseases, 12(2), 131-137.

The clinical spectrum of renal disease associated with human immunodeficiency virus. / Bourgoignie, J. J.; Meneses, R.; Ortiz, C.; Jaffe, D.; Pardo, V.

In: American Journal of Kidney Diseases, Vol. 12, No. 2, 01.01.1988, p. 131-137.

Research output: Contribution to journalArticle

Bourgoignie, JJ, Meneses, R, Ortiz, C, Jaffe, D & Pardo, V 1988, 'The clinical spectrum of renal disease associated with human immunodeficiency virus', American Journal of Kidney Diseases, vol. 12, no. 2, pp. 131-137.
Bourgoignie JJ, Meneses R, Ortiz C, Jaffe D, Pardo V. The clinical spectrum of renal disease associated with human immunodeficiency virus. American Journal of Kidney Diseases. 1988 Jan 1;12(2):131-137.
Bourgoignie, J. J. ; Meneses, R. ; Ortiz, C. ; Jaffe, D. ; Pardo, V. / The clinical spectrum of renal disease associated with human immunodeficiency virus. In: American Journal of Kidney Diseases. 1988 ; Vol. 12, No. 2. pp. 131-137.
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