TY - JOUR
T1 - The Clinical Significance of Mesangial IgM Deposits and Mesangial Hypercellularity in Minimal Change Nephrotic Syndrome
AU - Pardo, Victoriano
AU - Riesgo, Ignacio
AU - Zilleruelo, Gaston
AU - Strauss, Jose
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Some patients with minimal change nephrotic syndrome (MCNS) present on biopsy mesangial IgM deposits, which may be associated with mesangial hyperplasia. These patients have been considered as a possible subset with a different response to therapy as well as prognosis and designated as mesangial IgM nephropathy or mesangial proliferative glomerulonephritis. However, the clinical relevance of these biopsy findings has been questioned by others. We reviewed the clinical, biopsy, and follow-up data in 61 MCNS children, 33 with mesangial IgM and 28 free of immunoglobulins. There were no significant differences in response to therapy or prognosis between these two groups. The lack of IgM elution and heterologous in vitro C3 fixation in the biopsies of some MCNS cases with IgM mesangial deposits does not support the possibility that the deposited IgM plays an immunologic role.
AB - Some patients with minimal change nephrotic syndrome (MCNS) present on biopsy mesangial IgM deposits, which may be associated with mesangial hyperplasia. These patients have been considered as a possible subset with a different response to therapy as well as prognosis and designated as mesangial IgM nephropathy or mesangial proliferative glomerulonephritis. However, the clinical relevance of these biopsy findings has been questioned by others. We reviewed the clinical, biopsy, and follow-up data in 61 MCNS children, 33 with mesangial IgM and 28 free of immunoglobulins. There were no significant differences in response to therapy or prognosis between these two groups. The lack of IgM elution and heterologous in vitro C3 fixation in the biopsies of some MCNS cases with IgM mesangial deposits does not support the possibility that the deposited IgM plays an immunologic role.
KW - Idiopathic nephrosis
KW - mesangial IgM
KW - mesangial proliferation
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U2 - 10.1016/S0272-6386(84)80043-8
DO - 10.1016/S0272-6386(84)80043-8
M3 - Article
C2 - 6691342
AN - SCOPUS:0021365192
VL - 3
SP - 264
EP - 269
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 4
ER -