Abstract
Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.
| Original language | English |
|---|---|
| Pages (from-to) | 1990-1997 |
| Number of pages | 8 |
| Journal | American Journal of Transplantation |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2008 |
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Keywords
- Immunosuppression
- Islet transplantation
- Late complications of diabetes
- Type 1 diabetes mellitus
ASJC Scopus subject areas
- Immunology
Cite this
The clinical impact of islet transplantation. / Fiorina, P.; Shapiro, A. M J; Ricordi, Camillo; Secchi, A.
In: American Journal of Transplantation, Vol. 8, No. 10, 01.10.2008, p. 1990-1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The clinical impact of islet transplantation
AU - Fiorina, P.
AU - Shapiro, A. M J
AU - Ricordi, Camillo
AU - Secchi, A.
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.
AB - Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.
KW - Immunosuppression
KW - Islet transplantation
KW - Late complications of diabetes
KW - Type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=51849087695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51849087695&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2008.02353.x
DO - 10.1111/j.1600-6143.2008.02353.x
M3 - Article
C2 - 18828765
AN - SCOPUS:51849087695
VL - 8
SP - 1990
EP - 1997
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 10
ER -