The clinical impact of islet transplantation

P. Fiorina, A. M J Shapiro, Camillo Ricordi, A. Secchi

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.

Original languageEnglish
Pages (from-to)1990-1997
Number of pages8
JournalAmerican Journal of Transplantation
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2008

Fingerprint

Islets of Langerhans Transplantation
Cell Transplantation
Diabetes Complications
Islets of Langerhans
Insulin
Survival
Hypoglycemic Agents
Immunosuppression
Therapeutics
Transplantation
Quality of Life

Keywords

  • Immunosuppression
  • Islet transplantation
  • Late complications of diabetes
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Immunology

Cite this

The clinical impact of islet transplantation. / Fiorina, P.; Shapiro, A. M J; Ricordi, Camillo; Secchi, A.

In: American Journal of Transplantation, Vol. 8, No. 10, 01.10.2008, p. 1990-1997.

Research output: Contribution to journalArticle

Fiorina, P. ; Shapiro, A. M J ; Ricordi, Camillo ; Secchi, A. / The clinical impact of islet transplantation. In: American Journal of Transplantation. 2008 ; Vol. 8, No. 10. pp. 1990-1997.
@article{ae73c39584904193ab5a8f6e9b052ce3,
title = "The clinical impact of islet transplantation",
abstract = "Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60{\%} at 1 year posttransplantation compared with 15{\%} previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.",
keywords = "Immunosuppression, Islet transplantation, Late complications of diabetes, Type 1 diabetes mellitus",
author = "P. Fiorina and Shapiro, {A. M J} and Camillo Ricordi and A. Secchi",
year = "2008",
month = "10",
day = "1",
doi = "10.1111/j.1600-6143.2008.02353.x",
language = "English",
volume = "8",
pages = "1990--1997",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - The clinical impact of islet transplantation

AU - Fiorina, P.

AU - Shapiro, A. M J

AU - Ricordi, Camillo

AU - Secchi, A.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.

AB - Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients and, in many cases, achieving insulin independence. Unfortunately, many persistent flaws still prevent islet transplantation from becoming the gold standard treatment for type 1 diabetic patients. We review the state of the art of islet transplantation, outcomes, immunosuppression and - most important - the impact on patients' survival and long-term diabetic complications and eventual alternative options. Finally, we review the many problems in the field and the challenges to islet survival after transplantation. The rate of insulin independence 1 year after islet cell transplantation has significantly improved in recent years (60% at 1 year posttransplantation compared with 15% previously). Recent data indicate that restoration of insulin secretion after islet cell transplantation is associated with an improvement in quality of life, with a reduction in hypoglycemic episodes and potentially with a reduction in long-term diabetic complications. Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications.

KW - Immunosuppression

KW - Islet transplantation

KW - Late complications of diabetes

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=51849087695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51849087695&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2008.02353.x

DO - 10.1111/j.1600-6143.2008.02353.x

M3 - Article

C2 - 18828765

AN - SCOPUS:51849087695

VL - 8

SP - 1990

EP - 1997

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 10

ER -