The clinical application of gene editing: Ethical and social issues

Kelly E. Ormond, Yvonne Bombard, Vence L. Bonham, Lily Hoffman-Andrews, Heidi Howard, Rosario Isasi, Kiran Musunuru, Kirsten A. Riggan, Marsha Michie, Megan Allyse

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Gene-editing techniques have progressed rapidly in the past 5 years. There are already ongoing human somatic gene-editing clinical trials for multiple diseases. And there has been one purported scenario of human germline gene editing in late 2018. In this paper, we will review the current state of the technology, discuss the ethical and social issues that surround the various forms of gene editing, as well as review emerging stakeholder data from professionals, the 'general public' and individuals and families dealing with genetic diseases potentially treatable by gene editing.

Original languageEnglish (US)
Pages (from-to)337-350
Number of pages14
JournalPersonalized Medicine
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2019

Keywords

  • clinical trials
  • CRISPR
  • ethics
  • gene editing
  • genome editing
  • germline gene editing
  • professional attitudes
  • public attitudes
  • somatic gene editing
  • stakeholder research

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Ormond, K. E., Bombard, Y., Bonham, V. L., Hoffman-Andrews, L., Howard, H., Isasi, R., Musunuru, K., Riggan, K. A., Michie, M., & Allyse, M. (2019). The clinical application of gene editing: Ethical and social issues. Personalized Medicine, 16(4), 337-350. https://doi.org/10.2217/pme-2018-0155