The clearance of intravitreal gentamicin

L. M. Cobo, R. K. Forster

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Abstract

Intravitreal gentamicin cleared significantly more rapidly from the uninflamed aphakic rabbit eye than the phakic control, with a half-life of 12 hours in the former and 32 hours in the latter. A similar difference was noted in aphakic and phakic eyes with an experimental Staphylococcus aureus endophthalmitis, but without the same level of significance. Human data from nine aphakic infected eyes undergoing reinjection or vitrectomy indicated that therapeutic levels of gentamicin are not consistently found 48 hours or more after the initial intravitreal injection.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalAmerican journal of ophthalmology
Volume92
Issue number1
DOIs
StatePublished - Jan 1 1981

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ASJC Scopus subject areas

  • Ophthalmology

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