The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G

Vincenzo Cirulli, Jessie Zalatan, Michael McMaster, Robyn Prinsen, Daniel R. Salomon, Camillo Ricordi, Bruce E. Torbett, Paolo Meda, Laura Crisa

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109 Scopus citations

Abstract

Selective expression of the human class Ib HLA molecule HLA-G in immunologically protected sites and its function in the inhibition of NK and T-cell effector functions support an important role of this molecule in immunoregulation. Here, we demonstrate that HLA-G is constitutively expressed in the endocrine compartment of the human pancreas. Surface expression of this HLA determinant in endocrine cells is regulated in response to growth and inflammatory stimuli. Furthermore, we provide evidence that HLA-G expressed in this tissue may associate with a subset of insulin-containing granules and may be shuttled to the cell surface in response to secretory stimuli. Thus, HLA-G presentation by endocrine cells may be regulated in concert with their secretory activity. These results identify the expression of a major histocompatibility complex locus with putative regulatory functions in human pancreatic islets, a finding with potentially important implications for the progression of autoimmunity as well as for the establishment of transplant tolerance to this tissue.

Original languageEnglish (US)
Pages (from-to)1214-1222
Number of pages9
JournalDiabetes
Volume55
Issue number5
DOIs
StatePublished - Aug 15 2006

Keywords

  • IFN-γ, γ-interferon
  • IL, interleukin
  • INF-γ, γ-interferon
  • MHC, major histocompatibility complex
  • PECAM, platelet-endothelial cell adhesion molecule

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Cirulli, V., Zalatan, J., McMaster, M., Prinsen, R., Salomon, D. R., Ricordi, C., Torbett, B. E., Meda, P., & Crisa, L. (2006). The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G. Diabetes, 55(5), 1214-1222. https://doi.org/10.2337/db05-0731