The circulation of the airways: anatomy, physiology and potential role in drug delivery to the respiratory tract

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

As the pricipal source of blood flow to the conducting airways, the airway circulation can influence the metabolism and clearance of biologically active, locally released substances, the distribution of systemically administered pharmacologic agents to the airway and the absorption of inhaled pharmacologic agents from the airway. There are some preliminary experimental data in humans and other species which support this notion. However, the literature pertaining to the role of the airway circulation in drug delivery, absorption and metabolism is sparse. Nevertheless, a brief review of the anatomical and physiological properties of the airway circulation implies an important role for the airway circulation in the delivery or absorption of pharmacologic agents within the conducting airways.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalAdvanced Drug Delivery Reviews
Volume5
Issue number1-2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Airway circulation
  • Airway mucosal circulation
  • Airway perfusion
  • Airway vasculature
  • Bronchial circulation

ASJC Scopus subject areas

  • Pharmaceutical Science

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