The chromosome constitution of 1000 human spermatozoa

R. H. Martin, Wayne E Balkan, Kathy Burns, A. W. Rademaker, C. C. Lin, N. L. Rudd

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Chromosomal analysis of 1000 spermatozoa from 33 normal men was performed using in vitro fertilization of zonafree golden hamster eggs. The frequency of abnormal sperm complements was 8.5%: 5.2% were aneuploid and 3.3% had a structural chromosome abnormality. The frequencies of hyperhaploid (2.4%) and hypohaploid (2.7%) sperm complements were not significantly different and all chromosome groups were represented among the aneuploid complements. The majority (22/33) of structurally abnormal complements had a chromosome break. The percentages of X and Y-bearing sperm were 53.9% and 46.1%, which is significantly different from the expected one to one ratio.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalHuman Genetics
Volume63
Issue number4
DOIs
StatePublished - Jun 1983
Externally publishedYes

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Constitution and Bylaws
Spermatozoa
Chromosomes
Aneuploidy
Chromosome Breakage
Mesocricetus
Fertilization in Vitro
Chromosome Aberrations
Eggs

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Martin, R. H., Balkan, W. E., Burns, K., Rademaker, A. W., Lin, C. C., & Rudd, N. L. (1983). The chromosome constitution of 1000 human spermatozoa. Human Genetics, 63(4), 305-309. https://doi.org/10.1007/BF00274750

The chromosome constitution of 1000 human spermatozoa. / Martin, R. H.; Balkan, Wayne E; Burns, Kathy; Rademaker, A. W.; Lin, C. C.; Rudd, N. L.

In: Human Genetics, Vol. 63, No. 4, 06.1983, p. 305-309.

Research output: Contribution to journalArticle

Martin, RH, Balkan, WE, Burns, K, Rademaker, AW, Lin, CC & Rudd, NL 1983, 'The chromosome constitution of 1000 human spermatozoa', Human Genetics, vol. 63, no. 4, pp. 305-309. https://doi.org/10.1007/BF00274750
Martin RH, Balkan WE, Burns K, Rademaker AW, Lin CC, Rudd NL. The chromosome constitution of 1000 human spermatozoa. Human Genetics. 1983 Jun;63(4):305-309. https://doi.org/10.1007/BF00274750
Martin, R. H. ; Balkan, Wayne E ; Burns, Kathy ; Rademaker, A. W. ; Lin, C. C. ; Rudd, N. L. / The chromosome constitution of 1000 human spermatozoa. In: Human Genetics. 1983 ; Vol. 63, No. 4. pp. 305-309.
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