The chromosome constitution of 1000 human spermatozoa

R. H. Martin, W. Balkan, Kathy Burns, A. W. Rademaker, C. C. Lin, N. L. Rudd

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Chromosomal analysis of 1000 spermatozoa from 33 normal men was performed using in vitro fertilization of zonafree golden hamster eggs. The frequency of abnormal sperm complements was 8.5%: 5.2% were aneuploid and 3.3% had a structural chromosome abnormality. The frequencies of hyperhaploid (2.4%) and hypohaploid (2.7%) sperm complements were not significantly different and all chromosome groups were represented among the aneuploid complements. The majority (22/33) of structurally abnormal complements had a chromosome break. The percentages of X and Y-bearing sperm were 53.9% and 46.1%, which is significantly different from the expected one to one ratio.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalHuman Genetics
Volume63
Issue number4
DOIs
StatePublished - Jun 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Martin, R. H., Balkan, W., Burns, K., Rademaker, A. W., Lin, C. C., & Rudd, N. L. (1983). The chromosome constitution of 1000 human spermatozoa. Human Genetics, 63(4), 305-309. https://doi.org/10.1007/BF00274750