The changing spectrum of neonatal infectious disease

L. R W Plano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To understand the changing spectrum of neonatal infectious disease, one must first be familiar with the history, the variety of organisms and the progression of change of neonatal infections over the years. As progressively more immature neonates are surviving, the spectrum of infectious disease has changed in response to current medical practice responsible for this success and to selective pressures on the microorganisms. The surviving very low birth weight infants are at a significant risk for contracting infections from this expanding repertoire of pathogens. Microorganisms once thought seemingly benign and nonpathogenic are now commonly accepted as pathogens and are among the most likely organisms to cause infections in this extremely vulnerable patient population. When considering the possible identity of infecting organisms and attempting to tailor specific therapies to decrease unwanted consequences, one must consider the level of maturity and the age of neonate, as well as the intensity of care necessary for a successful outcome. This brief review focuses primarily on the changing spectrum of bacterial and fungal infections and will not substantially address viral infections.

Original languageEnglish
JournalJournal of Perinatology
Volume30
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 1 2010

Fingerprint

Infant, Newborn, Diseases
Communicable Diseases
Infection
Newborn Infant
Very Low Birth Weight Infant
Mycoses
Vulnerable Populations
Virus Diseases
Bacterial Infections
History

Keywords

  • early-onset sepsis
  • late-onset sepsis
  • neonatal infectious disease
  • neonatal sepsis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

The changing spectrum of neonatal infectious disease. / Plano, L. R W.

In: Journal of Perinatology, Vol. 30, No. SUPPL. 1, 01.10.2010.

Research output: Contribution to journalArticle

Plano, L. R W. / The changing spectrum of neonatal infectious disease. In: Journal of Perinatology. 2010 ; Vol. 30, No. SUPPL. 1.
@article{b14578ac2e9c4cab9dac935eb2ca076a,
title = "The changing spectrum of neonatal infectious disease",
abstract = "To understand the changing spectrum of neonatal infectious disease, one must first be familiar with the history, the variety of organisms and the progression of change of neonatal infections over the years. As progressively more immature neonates are surviving, the spectrum of infectious disease has changed in response to current medical practice responsible for this success and to selective pressures on the microorganisms. The surviving very low birth weight infants are at a significant risk for contracting infections from this expanding repertoire of pathogens. Microorganisms once thought seemingly benign and nonpathogenic are now commonly accepted as pathogens and are among the most likely organisms to cause infections in this extremely vulnerable patient population. When considering the possible identity of infecting organisms and attempting to tailor specific therapies to decrease unwanted consequences, one must consider the level of maturity and the age of neonate, as well as the intensity of care necessary for a successful outcome. This brief review focuses primarily on the changing spectrum of bacterial and fungal infections and will not substantially address viral infections.",
keywords = "early-onset sepsis, late-onset sepsis, neonatal infectious disease, neonatal sepsis",
author = "Plano, {L. R W}",
year = "2010",
month = "10",
day = "1",
doi = "10.1038/jp.2010.92",
language = "English",
volume = "30",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "SUPPL. 1",

}

TY - JOUR

T1 - The changing spectrum of neonatal infectious disease

AU - Plano, L. R W

PY - 2010/10/1

Y1 - 2010/10/1

N2 - To understand the changing spectrum of neonatal infectious disease, one must first be familiar with the history, the variety of organisms and the progression of change of neonatal infections over the years. As progressively more immature neonates are surviving, the spectrum of infectious disease has changed in response to current medical practice responsible for this success and to selective pressures on the microorganisms. The surviving very low birth weight infants are at a significant risk for contracting infections from this expanding repertoire of pathogens. Microorganisms once thought seemingly benign and nonpathogenic are now commonly accepted as pathogens and are among the most likely organisms to cause infections in this extremely vulnerable patient population. When considering the possible identity of infecting organisms and attempting to tailor specific therapies to decrease unwanted consequences, one must consider the level of maturity and the age of neonate, as well as the intensity of care necessary for a successful outcome. This brief review focuses primarily on the changing spectrum of bacterial and fungal infections and will not substantially address viral infections.

AB - To understand the changing spectrum of neonatal infectious disease, one must first be familiar with the history, the variety of organisms and the progression of change of neonatal infections over the years. As progressively more immature neonates are surviving, the spectrum of infectious disease has changed in response to current medical practice responsible for this success and to selective pressures on the microorganisms. The surviving very low birth weight infants are at a significant risk for contracting infections from this expanding repertoire of pathogens. Microorganisms once thought seemingly benign and nonpathogenic are now commonly accepted as pathogens and are among the most likely organisms to cause infections in this extremely vulnerable patient population. When considering the possible identity of infecting organisms and attempting to tailor specific therapies to decrease unwanted consequences, one must consider the level of maturity and the age of neonate, as well as the intensity of care necessary for a successful outcome. This brief review focuses primarily on the changing spectrum of bacterial and fungal infections and will not substantially address viral infections.

KW - early-onset sepsis

KW - late-onset sepsis

KW - neonatal infectious disease

KW - neonatal sepsis

UR - http://www.scopus.com/inward/record.url?scp=77957591561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957591561&partnerID=8YFLogxK

U2 - 10.1038/jp.2010.92

DO - 10.1038/jp.2010.92

M3 - Article

C2 - 20877402

AN - SCOPUS:77957591561

VL - 30

JO - Journal of Perinatology

JF - Journal of Perinatology

SN - 0743-8346

IS - SUPPL. 1

ER -