The cerebral representation of scratching-induced pleasantness

Hideki Mochizuki, Satoshi Tanaka, Tomoyo Morita, Toshiaki Wasaka, Norihiro Sadato, Ryusuke Kakigi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Itch is an unpleasant sensation with the desire to scratch. Although it is well known that scratching itchy skin is pleasurable, the cerebral mechanisms underlying this phenomenon are poorly understood. We hypothesized that the reward system is associated with scratching-induced pleasantness. To investigate this hypothesis, a functional magnetic resonance imaging study was performed in 16 healthy subjects. Pleasantness was evoked by scratching the wrists where itch stimuli were applied, while scratching the dorsal forearms, far from itch stimuli, did not evoke pleasantness. Interestingly, pleasantness evoked by scratching activated not only the reward system (i.e., the striatum and midbrain) but also key regions of perception (i.e., the primary somatosensory cortex) and awareness of subjective feelings (i.e., the insular cortex), indicating that a broad network is involved in scratching-induced pleasantness. Moreover, although itch was suppressed by scratching, motorrelated regions such as the supplementary motor area, premotor cortex, and cerebellum showed significant activation when pleasantness was evoked. This activation could explain why scratchinginduced pleasantness potentially reinforces scratching behaviors. This study is the first to identify networks activated by scratching-induced pleasantness. The results of the present study provide important information on the cerebral mechanisms underlying why scratching itchy skin evokes pleasurable feelings that reinforce scratching behaviors.

Original languageEnglish (US)
Pages (from-to)488-498
Number of pages11
JournalJournal of Neurophysiology
Volume111
Issue number3
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Motor Cortex
Reward
Emotions
Skin
Somatosensory Cortex
Mesencephalon
Wrist
Forearm
Cerebral Cortex
Cerebellum
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • fMRI
  • Itch
  • Motor-related regions
  • Pleasantness of scratching
  • Reward system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Mochizuki, H., Tanaka, S., Morita, T., Wasaka, T., Sadato, N., & Kakigi, R. (2014). The cerebral representation of scratching-induced pleasantness. Journal of Neurophysiology, 111(3), 488-498. https://doi.org/10.1152/jn.00374.2013

The cerebral representation of scratching-induced pleasantness. / Mochizuki, Hideki; Tanaka, Satoshi; Morita, Tomoyo; Wasaka, Toshiaki; Sadato, Norihiro; Kakigi, Ryusuke.

In: Journal of Neurophysiology, Vol. 111, No. 3, 01.02.2014, p. 488-498.

Research output: Contribution to journalArticle

Mochizuki, H, Tanaka, S, Morita, T, Wasaka, T, Sadato, N & Kakigi, R 2014, 'The cerebral representation of scratching-induced pleasantness', Journal of Neurophysiology, vol. 111, no. 3, pp. 488-498. https://doi.org/10.1152/jn.00374.2013
Mochizuki, Hideki ; Tanaka, Satoshi ; Morita, Tomoyo ; Wasaka, Toshiaki ; Sadato, Norihiro ; Kakigi, Ryusuke. / The cerebral representation of scratching-induced pleasantness. In: Journal of Neurophysiology. 2014 ; Vol. 111, No. 3. pp. 488-498.
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