The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice

Takafumi Fuchiwaki, Xun Sun, Kenjiro Fujimura, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Eckhard R. Podack, Hideyuki Kawauchi, Yasunobu Yoshikai

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

CD30 ligand (CD30L) plays an important role in the amplification and/or activation of effector CD4 + T cells, irrespective of Th cell subset. To examine the role of CD30L in allergic rhinitis, we evaluated an OVA model of allergic rhinitis in CD30L knock out (KO) mice on a BALB/c background sensitized with OVA. Symptoms of allergic rhinitis such as eosinophil infiltration into the nasal mucosa were drastically diminished in OVA-sensitized CD30L KO mice following intranasal challenge with OVA. The levels of OVA-specific IgE in the sera and the Th2 response in nasopharynx-associated lymphoid tissues and cervical LNs of CD30L KO mice were significantly lower than those of WT mice following intranasal challenge with OVA. Intranasal administration of CD30-Ig during the effector phase with OVA significantly prevented the development of allergic rhinitis in WT mice. These results suggest that CD30L plays an important role in allergic rhinitis and that the inhibition of CD30L/CD30 signaling might be useful as a novel biological therapy for allergic rhinitis.

Original languageEnglish (US)
Pages (from-to)2947-2954
Number of pages8
JournalEuropean Journal of Immunology
Volume41
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Allergic rhinitis animal model
  • CD30L
  • Soluble CD30-Ig
  • Th2 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice'. Together they form a unique fingerprint.

  • Cite this

    Fuchiwaki, T., Sun, X., Fujimura, K., Yamada, H., Shibata, K., Muta, H., Podack, E. R., Kawauchi, H., & Yoshikai, Y. (2011). The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. European Journal of Immunology, 41(10), 2947-2954. https://doi.org/10.1002/eji.201141423