The CARMA1-Bcl10 Signaling Complex Selectively Regulates JNK2 Kinase in the T Cell Receptor-Signaling Pathway

Marzenna Blonska, Bhanu P. Pappu, Reiko Matsumoto, Hongxiu Li, Bing Su, Demin Wang, Xin Lin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Members of the c-Jun NH2-terminal kinase (JNK) family play crucial roles in cell activation, differentiation, and apoptosis. Although many studies have indicated that JNK1 and JNK2 have functional differences and redundancy, the upstream signaling pathway that selectively activates JNK1 or JNK2 remains unknown. In this study, we have revealed a selective mechanism of JNK activation, in which JNK2, but not JNK1, was regulated by CARMA1, a scaffold molecule, after stimulation of the T cell receptor (TCR). This CARMA1-dependent regulation of JNK2 worked through the scaffold molecule Bcl10, which was inducibly associated with JNK2 and served as a JNK-interacting protein (JIP)-like scaffold to assemble the kinases JNK2, MKK7, and TAK1. Finally, we showed that CARMA1- and Bcl10-mediated JNK2 activation had a critical role in regulating the amount of c-Jun protein. Together, our studies provide genetic evidence that JNK1 and JNK2 are differentially regulated in the TCR-signaling pathway and play different functions.

Original languageEnglish (US)
Pages (from-to)55-66
Number of pages12
JournalImmunity
Volume26
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

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Mitogen-Activated Protein Kinase 9
JNK Mitogen-Activated Protein Kinases
T-Cell Antigen Receptor
Proto-Oncogene Proteins c-jun
Cell Differentiation
Apoptosis
Proteins

Keywords

  • MOLIMMUNO
  • SIGNALING

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

The CARMA1-Bcl10 Signaling Complex Selectively Regulates JNK2 Kinase in the T Cell Receptor-Signaling Pathway. / Blonska, Marzenna; Pappu, Bhanu P.; Matsumoto, Reiko; Li, Hongxiu; Su, Bing; Wang, Demin; Lin, Xin.

In: Immunity, Vol. 26, No. 1, 01.2007, p. 55-66.

Research output: Contribution to journalArticle

Blonska, Marzenna ; Pappu, Bhanu P. ; Matsumoto, Reiko ; Li, Hongxiu ; Su, Bing ; Wang, Demin ; Lin, Xin. / The CARMA1-Bcl10 Signaling Complex Selectively Regulates JNK2 Kinase in the T Cell Receptor-Signaling Pathway. In: Immunity. 2007 ; Vol. 26, No. 1. pp. 55-66.
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