Abstract
The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
| Original language | English |
|---|---|
| Pages (from-to) | 247-255 |
| Number of pages | 9 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2010 |
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Keywords
- Age at onset
- Alzheimer's disease
- apolipoprotein E
- CALHM1
- polymorphism
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
Cite this
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease : A meta-analysis study. / Lambert, Jean Charles; Sleegers, Kristel; González-Pérez, Antonio; Ingelsson, Martin; Beecham, Gary W; Hiltunen, Mikko; Combarros, Onofre; Bullido, Maria J.; Brouwers, Nathalie; Bettens, Karolien; Berr, Claudine; Pasquier, Florence; Richard, Florence; Dekosky, Steven T.; Hannequin, Didier; Haines, Jonathan L.; Tognoni, Gloria; Fiévet, Nathalie; Dartigues, Jean François; Tzourio, Christophe; Engelborghs, Sebastiaan; Arosio, Beatrice; Coto, Elicer; De Deyn, Peter; Del Zompo, Maria; Mateo, Ignacio; Boada, Merce; Antunez, Carmen; Lopez-Arrieta, Jesus; Epelbaum, Jacques; Schjeide, Brit Maren Michaud; Frank-Garcia, Ana; Giedraitis, Vilmentas; Helisalmi, Seppo; Porcellini, Elisa; Pilotto, Alberto; Forti, Paola; Ferri, Raffaele; Delepine, Marc; Zelenika, Diana; Lathrop, Mark; Scarpini, Elio; Siciliano, Gabriele; Solfrizzi, Vincenzo; Sorbi, Sandro; Spalletta, Gianfranco; Ravaglia, Giovanni; Valdivieso, Fernando; Vepsäläinen, Saila; Alvarez, Victoria; Bosco, Paolo; Mancuso, Michelangelo; Panza, Francesco; Nacmias, Benedetta; Bossù, Paola; Hanon, Olivier; Piccardi, Paola; Annoni, Giorgio; Mann, David; Marambaud, Philippe; Seripa, Davide; Galimberti, Daniela; Tanzi, Rudolph E.; Bertram, Lars; Lendon, Corinne; Lannfelt, Lars; Licastro, Federico; Campion, Dominique; Pericak-Vance, Margaret A; Soininen, Hilkka; Van Broeckhoven, Christine; Alpérovitch, Annick; Ruiz, Agustin; Kamboh, M. Ilyas; Amouyel, Philippe.
In: Journal of Alzheimer's Disease, Vol. 22, No. 1, 01.12.2010, p. 247-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease
T2 - A meta-analysis study
AU - Lambert, Jean Charles
AU - Sleegers, Kristel
AU - González-Pérez, Antonio
AU - Ingelsson, Martin
AU - Beecham, Gary W
AU - Hiltunen, Mikko
AU - Combarros, Onofre
AU - Bullido, Maria J.
AU - Brouwers, Nathalie
AU - Bettens, Karolien
AU - Berr, Claudine
AU - Pasquier, Florence
AU - Richard, Florence
AU - Dekosky, Steven T.
AU - Hannequin, Didier
AU - Haines, Jonathan L.
AU - Tognoni, Gloria
AU - Fiévet, Nathalie
AU - Dartigues, Jean François
AU - Tzourio, Christophe
AU - Engelborghs, Sebastiaan
AU - Arosio, Beatrice
AU - Coto, Elicer
AU - De Deyn, Peter
AU - Del Zompo, Maria
AU - Mateo, Ignacio
AU - Boada, Merce
AU - Antunez, Carmen
AU - Lopez-Arrieta, Jesus
AU - Epelbaum, Jacques
AU - Schjeide, Brit Maren Michaud
AU - Frank-Garcia, Ana
AU - Giedraitis, Vilmentas
AU - Helisalmi, Seppo
AU - Porcellini, Elisa
AU - Pilotto, Alberto
AU - Forti, Paola
AU - Ferri, Raffaele
AU - Delepine, Marc
AU - Zelenika, Diana
AU - Lathrop, Mark
AU - Scarpini, Elio
AU - Siciliano, Gabriele
AU - Solfrizzi, Vincenzo
AU - Sorbi, Sandro
AU - Spalletta, Gianfranco
AU - Ravaglia, Giovanni
AU - Valdivieso, Fernando
AU - Vepsäläinen, Saila
AU - Alvarez, Victoria
AU - Bosco, Paolo
AU - Mancuso, Michelangelo
AU - Panza, Francesco
AU - Nacmias, Benedetta
AU - Bossù, Paola
AU - Hanon, Olivier
AU - Piccardi, Paola
AU - Annoni, Giorgio
AU - Mann, David
AU - Marambaud, Philippe
AU - Seripa, Davide
AU - Galimberti, Daniela
AU - Tanzi, Rudolph E.
AU - Bertram, Lars
AU - Lendon, Corinne
AU - Lannfelt, Lars
AU - Licastro, Federico
AU - Campion, Dominique
AU - Pericak-Vance, Margaret A
AU - Soininen, Hilkka
AU - Van Broeckhoven, Christine
AU - Alpérovitch, Annick
AU - Ruiz, Agustin
AU - Kamboh, M. Ilyas
AU - Amouyel, Philippe
PY - 2010/12/1
Y1 - 2010/12/1
N2 - The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
AB - The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
KW - Age at onset
KW - Alzheimer's disease
KW - apolipoprotein E
KW - CALHM1
KW - polymorphism
UR - http://www.scopus.com/inward/record.url?scp=78650654190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650654190&partnerID=8YFLogxK
U2 - 10.3233/JAD-2010-100933
DO - 10.3233/JAD-2010-100933
M3 - Article
VL - 22
SP - 247
EP - 255
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 1
ER -