The c-wave of the electroretinogram recorded under clinical conditions from rabbits

D. I. Hamasaki, Kalyani Korabathina, Sheetal R. Patel, M. U. Liu, Byron L. Lam

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


To determine whether large and repeatable c-waves can be recorded from rabbits with equipment already in use in clinical electroretinographic laboratories, the Burian-Allen electrode, connected bipolarly or monopolarly, was used to record electroretinograms from pigmented rabbits. The Jet electrode was also used. The c-waves elicited by long-duration (4-second) stimuli were compared to those elicited by stroboscopic stimuli. In addition, the c-waves recorded with direct-coupled amplification were compared to those recorded with condenser-coupled amplification (one-half-amplitude bandpass=0.1 Hz). The b-wave amplitude was not altered by the amplifier coupling or by the two stimulus durations. The largest c-waves were elicited by 4-second-duration stimuli and recorded with direct-coupled amplification. Although the c-wave amplitude was reduced by stroboscopic stimuli and by condenser coupling, large and repeatable c-waves were elicited by stroboscopic stimuli and recorded with condenser-coupled amplification. A comparison of stimulus duration and amplifier coupling showed that the stimulus duration was more important in recording large-amplitude c-waves. Similar results were obtained with the Jet electrode. We conclude that repeatable and large c-waves can be elicited by a stroboscopic stimuli and can be recorded with condenser-coupled amplification with good low-frequency response from rabbits.

Original languageEnglish (US)
Pages (from-to)365-381
Number of pages17
JournalDocumenta Ophthalmologica
Issue number4
StatePublished - 1997

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)


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