The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats

Ilze Ducis, Luz Oliva B. Norenberg, Michael D. Norenberg

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalBrain Research
Volume531
Issue number1-2
DOIs
StatePublished - Oct 29 1990

Keywords

  • Astrocyte
  • Epilepsy
  • Peripheral-type benzodiazepine receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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