The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats

Ilze Ducis; Luz Oliva B. Norenberg; Michael D. Norenberg

doi:10.1016/0006-8993(90)90793-B

The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats

Ilze Ducis, Luz Oliva B. Norenberg, Michael D. Norenberg

Pathology

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [³H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (B_max) as compared to controls. No significant change in affinity (K_d) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.

Original language	English (US)
Pages (from-to)	318-321
Number of pages	4
Journal	Brain research
Volume	531
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(90)90793-B
State	Published - Oct 29 1990

Keywords

Astrocyte
Epilepsy
Peripheral-type benzodiazepine receptor

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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abstract = "Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.",

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AU - Norenberg, Michael D.

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AB - Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.

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KW - Epilepsy

KW - Peripheral-type benzodiazepine receptor

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The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats

Abstract

Keywords

ASJC Scopus subject areas

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