Abstract
Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 318-321 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 531 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 29 1990 |
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Keywords
- Astrocyte
- Epilepsy
- Peripheral-type benzodiazepine receptor
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats. / Ducis, Ilze; Norenberg, Luz Oliva B; Norenberg, Michael D.
In: Brain Research, Vol. 531, No. 1-2, 29.10.1990, p. 318-321.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats
AU - Ducis, Ilze
AU - Norenberg, Luz Oliva B
AU - Norenberg, Michael D
PY - 1990/10/29
Y1 - 1990/10/29
N2 - Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
AB - Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
KW - Astrocyte
KW - Epilepsy
KW - Peripheral-type benzodiazepine receptor
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U2 - 10.1016/0006-8993(90)90793-B
DO - 10.1016/0006-8993(90)90793-B
M3 - Article
C2 - 1963103
AN - SCOPUS:0025110472
VL - 531
SP - 318
EP - 321
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -