Abstract
Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 318-321 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 531 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 29 1990 |
Keywords
- Astrocyte
- Epilepsy
- Peripheral-type benzodiazepine receptor
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Ducis, I., Norenberg, L. O. B., & Norenberg, M. D. (1990). The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats. Brain Research, 531(1-2), 318-321. https://doi.org/10.1016/0006-8993(90)90793-B